Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (12): 2137-2140.doi: 10.3969/j.issn.1673-8225.2010.12.012

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Biological safety assessment of a new machinable bioactive glass-ceramic

Hao Yu-quan1, Gao Ying-jiao2, Qin Xiao-mei3, Han Xue-song4, Liu Min-da5, Ai Hong-jun1   

  1. 1 Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang  110002, Liaoning Province, China; 2 Department of Orthodontics, School of Stomatology, China Medical University, Shenyang  110002, Liaoning Province, China; 3 College of Materials and Metallurgy, Northeastern University, Shenyang 110004, Liaoning Province, China; 4 Department of Stomatology, Liaoning Provincial Corps Hospital of Chinese People’s Armed Police Forces, Shenyang  110034, Liaoning Province, China; 5 School of Stomatology, China Medical University, Shenyang  110002, Liaoning Province, China
  • Online:2010-03-19 Published:2010-03-19
  • Contact: Ai Hong-jun, Professor, Chief physician, Doctoral supervisor, Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China aih0620@yahoo.com.cn
  • About author:Hao Yu-quan★, Master, Lecturer, Attending physician, Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China yqhao056@163.com

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Abstract:

BACKGROUND: The machinable bioactive glass-ceramic we designed recently have a lower melting temperature, and preparation of cost while bending strength in ensuring the same time. Prior to clinical application, biocompatibility should be evaluated.
OBJECTIVE: To observe the new machinable bioactive glass-ceramics on the availability of systemic toxicity in mice and evaluate its biological security.
METHODS: The Kunming mice were randomly divided into an experimental group, negative control group and positive control group. Mice in experimental group were orally perfused with the suspension of machinable bioactive glass-ceramics and Arabic gum. While the mice in the negative control group were treated with an equal volume of Arabic gum, and the mice in the positive control group were treated with an equal volume of lead acetate solution. The general state and toxicity of mice were observed and body mass was recorded after 24 hours, 48 hours, and 72 hours. Finally the mice were sacrificed, and the morphological changes in liver and kidney were then examined by light and electron microscopy.
RESULTS AND CONCLUSION: The body mass of mice in the experimental group was not decreased significantly compared with the mice in the negative control group in 72 hours (P > 0.05). Pathological changes of liver and kidney in the experimental group did not be found. The new machinable bioactive glass-ceramic did not show systemic toxicity for a short term.

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