Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (8): 1491-1494.doi: 10.3969/j.issn.1673-8225.2010.08.039

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Treatment of bronchopleural fistula using injection of fibrin sealant combined with microwave under endoscope in 8 cases

Liu Jian-ming 1,2, Liu Xin-min3, Sun Sheng-hua1, Zhang Yang-de2, Liu Bei-zhan1   

  1. 1 Department of Respiratory Diseases, Third Xiangya Hospital of Central South University, Changsha  410078, Hunan Province, China; 2 Institute of Biomedical Engineering, 3 Public Health School, Central South University, Changsha  410078, Hunan Province, China
  • Online:2010-02-19 Published:2010-02-19
  • Contact: Liu Xin-min, Master, Lecturer, Public Health School of Central South University, Changsha 410078, Hunan Province, China liuxinmin42@xysm.net
  • About author:Liu Jian-ming☆, Doctor, Attending physician, Department of Respiratory Diseases, Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China; Institute of Biomedical Engineering, Central South University, Changsha 410078, Hunan Province, China Liujianming101@sina.com

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Abstract:

BACKGROUND: Traditional treatment includes conservative therapy and surgical treatment on bronchial pleural fistula. With the development of endoscopic therapy, a new safe and effective method is concerned.
OBJECTIVE: To summarize the therapeutic effect of treating bronchopleural fistula using bronchoscopy-guided injection of fibrin sealant combined with gelatin sponge filled and microwave following after lung resection.
METHODS: Totally 8 cases of bronchial fistula patients were received injection of fibrin sealant after microwave and gelatin sponge filled by bronchoscopy, including 6 males and 2 females, mean aged 53.8 years (39-73 year-old). Cases 1 and 2 received left upper pulmonary lobectomy, cases 3 received left lower pulmonary lobectomy, case 4 received right lower pulmonary lobectomy, cases 5 and 6 received right upper pulmonary lobectomy, and the cases 7 and 8 received pneumonectomy. bronchopleural fistula occurred after postoperative Chemotherapy in cases 4 and 8.
RESULTS AND CONCLUSION: The case 8 was failed to treatment due to the large orificium fistulae (> 5 mm) and disappointed results after 6 times plugging. The other 7 patients were cured successfully. The injection time was correlated to the size of orificium fistulae, and the plugging was successful for 4 patients with less than 3 mm orificium fistulae. However, a third or fifth plugging was performed for 3 cases with 3-5 mm orificium fistulae. No surgery-related complications occurred in all patients. Bronchoscopy guided injection of fibrin sealant combined with gelatin sponge and microwave is a safe and effective method for bronchial fistula.

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