Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3775-3777.doi: 10.3969/j.issn.1673-8225.2011.20.040

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Interaction effects between AMP-activated protein kinase and mammalian target of rapamycin signaling pathways

Xu Fei   

  1. Institute of Sports Scientific Research, Zhejiang University of Technology, Hangzhou  310023, Zhejiang Province, China
  • Received:2010-01-04 Revised:2011-03-11 Online:2011-05-14 Published:2011-05-14
  • About author:Xu Fei☆, Doctor, Lecturer, Institute of Sports Scientific Research, Zhejiang University of Technology, Hangzhou 310023, Zhejiang Province, China yangt1193@gmail. com

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Abstract:

BACKGROUND: The mammalian target of rapamycin (mTOR), a target protein of downstream AMP-activated protein kinase (AMPK), is a positive effector for cell growth, division and protein synthesis.
OBJECTIVE: To summarize research progress concerning the regulation of mTOR signaling transduction by AMPK and the interaction effects of each other.
METHODS: The author use the words of (mammalian target of rapamycin OR mTOR) AND (AMP activated protein kinase OR AMPK) AND signal transduction” by restriction fields of title/abstract in PubMed database. Totally 30 papers related to interaction effects of mTOR signaling transduction and AMPK were included.
RESULTS AND CONCLUSION: AMPK activation reduces mTOR signal transduction, to some extent, inhibits protein synthesis. AMPK regulates mTOR signal transduction through phosphorylation and activation at multiple sites. AMPK phosphorylation of tuberin inhibits effective of Akt, ERK1/ERK2, and p90rsk the other protein kinases. In addition, clarify the regulation of AMPK on the mTOR plays an important role in revealing AMPK-mTOR passageways in controlling energy metabolism and protein synthesis.

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