Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3771-3774.doi: 10.3969/j.issn.1673-8225.2011.20.039

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Transmembrane signal transduction pathway of leptin effects on wound healing

Wu Guo-hui, Li Xiao-lin, Liu Yi-zheng   

  1. Department of Plastic and Maxillofacial Surgery, Jiangxi Province People’s Hospital, Nanchang  330006, Jiangxi Province, China
  • Received:2010-12-03 Revised:2011-03-12 Online:2011-05-14 Published:2011-05-14
  • About author:Wu Guo-hui★, Master, Associate chief physician, Master’s supervisor, Department of Plastic and Maxillofacial Surgery, Jiangxi Province People’s Hospital, Nanchang 330006, Jiangxi Province, China wu_gh@163.com
  • Supported by:

    the Science and Technology Support Project of Jiangxi Province, No. 2008-054*, 2009ZDS15900*; Science and Technology Program of Jiangxi Provincial Health Committee, No. 20083016*

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Abstract:

BACKGROUND: When combined with its receptor, leptin can promote angiogenesis; modulate inflammation and immune function by means of endocrine, paracrine and other ways.
OBJECTIVE: To discuss and summarize the effect of leptin on wound healing and the mechanism of leptin transmembrane signal transduction.
METHODS: A computer retrieval of CNKI and PubMed databases was performed by using “leptin, wound healing, transmembrane signal” as key words in Chinese and English.
RESULTS AND DISCUSSION: Totally 78 articles were retrieved. According to inclusion and exclusion criteria, 22 articles were included after screening. The results showed that leptin plays an important role in wound healing, and it can promote the proliferation and migration of epidermal keratinocytes. We also found that JAK2, STST3, ERK1, and other signal molecules are involved in the transmembrane signal transduction of leptin.

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