Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4423-4426.doi: 10.3969/j.issn.1673-8225.2011.24.013

Previous Articles     Next Articles

Phosphorylated p38 mitogen-activated protein kinase and transforming growth factor beta-1 expression in degenerative versus normal disc tissues

Yuan Ye1, Zhao Jing2, Zhao Jie2, Li Yong-min1, Wang Xu1   

  1. 1Department of Spine Surgery, Tangshan Second Hospital, Tangshan  063000, Hebei Province, China
    2Department of Pathology, Hebei Union University, Tangshan  063000, Hebei Province, China
  • Received:2011-03-07 Revised:2011-05-06 Online:2011-06-11 Published:2011-06-11
  • Contact: Zhao Jing, Master, Associate professor, Master’s supervisor, Department of Pathology, Hebei Union University, Tangshan 063000, Hebei Province, China yuanyets@163.com
  • About author:Yuan Ye★, Master, Associate chief physician, Department of Spine Surgery, Tangshan Second Hospital, Tangshan 063000, Hebei Province, China yuanyets@163.com Zhao Jing, Master, Associate professor, Master’s supervisor, Department of Pathology, Hebei Union University, Tangshan 063000, Hebei Province, China yuanyets@163.com Yuan Ye and Zhao Jing contributed equally to this paper.
  • Supported by:

     the Natural Science Foundation of Education Department of Hebei Province, No. Z2005102*; the Science and Technology Development Program of Hebei Province, No. 052761422*

PDF

390

Abstract:

BACKGROUND: Studies show that p38 mitogen activated protein kinase (MAPK) signal pathway is highly correlated with inflammatory reactions during intervertebral disc degeneration.
OBJECTIVE: To study the phosphorylated p38MAPK (p-p38MAPK) and transforming growth factor β1 (TGF-β1) expression in patients with intervertebral disc degeneration.
METHODS: Degenerative disc tissues resected by surgery from 36 patients with lumbar disc herniation were selected and normal disc tissues from 10 cases of trauma were used as control group. The expression of p-p38MAPK and TGF-β1 was evaluated with immunohistochemistry method and analyzed using pathological imaging analysis system.
RESULTS AND CONCLUSION: The positive rate of p-p38MAPK and TGF-β1 expression in degenerative disc tissues was greater than normal disc tissue (P < 0.05). Results demonstrated that p-p38MAPK and TGF-β1 are highly expressed in the process of disc degeneration.

CLC Number: