Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4371-4374.doi: 10.3969/j.issn.1673-8225.2011.24.001

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Point implantation of allograft chondrocytes for repairing articular cartilage defects

Chen Yi-quan1, Shen Hui-liang2, Yong Yi-min2, Hu Huai-jian2   

  1. 1Department of Orthopedics, Second People’s Hospital of Longgang, Shenzhen  518112, Guangdong Province, China
    2Department of Orthopedics, Xuanwu Hospital Affiliated to Capital Medical University, Beijing  100053, China
  • Received:2011-03-12 Revised:2011-05-06 Online:2011-06-11 Published:2011-06-11
  • About author:Chen Yi-quan★, Master, Associate chief physician, Department of Orthopedics, Second People’s Hospital of Longgang, Shenzhen 518112, Guangdong Province, China chyiq2000@yahoo.com

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Abstract:

BACKGROUND: Although many biological reconstruction can repair defects and rebuild articular surfaces, the function is inferior to normal cartilage. Transplantation of biodegradable polymer-coated cartilage cells may obtain real hyaline cartilage.
OBJECTIVE: To observe effects of collagen-embedded chondrocytes by point implantation method on repairing articular cartilage defects.
METHODS: Articular cartilage defects were made in the knee of New Zealand rabbits. The rabbits were randomly divided into three groups, treated with collagen gel-embedded chondrocytes, chondrocytes or no treatment.
RESULTS AND CONCLUSION: Histological changes were observed at 2, 4, 12 and 24 weeks postoperatively. Hyaline cartilage was observed in rabbits following transplantation of collagen gel-embedded chondrocytes, while only fibrous tissues were observed in the defects in the other two groups. Moreover, mean histological and histochemical scores were greater in the rabbits treated with collagen gel-embedded chondrocytes compared with the other groups (P < 0.01). Results show that transplantation of collagen gel-embedded chondrocytes can obtain hyaline cartilage, and can be used for repairing large-area cartilage defects.

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