Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3662-3665.doi: 10.3969/j.issn.1673-8225.2011.20.013

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Mechanical properties variations of rat vertebra osteoporosis secondary to spinal cord injury

Sun Shu-dong1, Gao Ming2, Li Xin-ying2, Quan Tie-gang2, Ma Hong-shun3   

  1. 1Second Hospital of Jilin University, Changchun  130036, Jilin Province, China
    2China-Japan Union Hospital of Jilin University, Changchun  130031, Jilin Province, China
    3Department of Engineering Mechanics, Nanling Campus, Jilin University, Changchun  130022, Jilin Province, China
  • Received:2010-11-12 Revised:2010-12-16 Online:2011-05-14 Published:2011-05-14
  • Contact: Sun Shu-dong★, Master, Associate professor, Second Hospital of Jilin University, Changchun 130036, Jilin Province, China mahs@jlu.edu.cn
  • About author:Sun Shu-dong★, Master, Associate professor, Second Hospital of Jilin University, Changchun 130036, Jilin Province, China mahs@jlu.edu.cn

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Abstract:

BACKGROUND: Spinal cord injury lead to muscular atrophy of lower extremity and evoke osteoporosis following a long duration. It is necessary to study the mechanical properties of animal models with osteoporosis secondary to spinal cord injury.
OBJECTIVE: To observe spinal cord injury-induced mechanical changes of vertebra.
METHODS: Totally 66 Wistar, male, rats were randomly divided into the control and model groups. Spinal cord was injured by cutting vertebral plate at T10 centrum horizontally. L1-4 vertebra was harvested at 11 weeks after model preparation for compression, torsion and impulse tests.
RESULTS AND CONCLUSION: Compared with the control group, the maximum load, maximum stress, maximum torque, maximum stress, maximum torsion angle, maximum impact energy, and maximum impact toughness of the model group were smaller (P < 0.05), suggesting that there are variations in compression, torsion and impulse features of rat vertebra osteoporosis secondary to spinal cord injury. 

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