Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (36): 6800-6804.doi: 10.3969/j.issn.1673-8225.2010.36.034

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Application progress of mesenchymal stem cells in tissue engineering   

Wang Fu-ke1, Liu Liu1, Li Jun-nan1, Zhao De-ping2, Dai Xiao-ming1, Li Yi-song1, He Xiao-guang1   

  1. 1 Department of Head and Neck Surgery, 2 Experimental Center, First Affiliated Hospital, Kunming Medical University, Kunming  650032, Yunnan Province, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Liu Liu, Professor, Doctor, Doctoral supervisor, Department of Head and Neck Surgery, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China liuliu3939@126.com
  • About author:Wang Fu-ke☆, Doctor, Lecturer, Department of Head and Neck Surgery, First Affiliated Hospital, Kunming Medical University, Kunming 650032, Yunnan Province, China wfk.04@126.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30960388*; the Association Special Project of Department of Science and Technology of Yunnan Province, No. 2007C0007R*; the Doctor Innovation Foundation of Kunming Medical University, No. KM2007D03*

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Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) form connective tissue and organ interstitial in the body. MSCs are characterized by strong proliferative ability, multi-differentiation potential and immunomodulation. With advantages such as convenient source, easy to separate, culture, amplify and purificate, MSCs play an important role in tissue engineering and gene therapy research.
OBJECTIVE: To review biological proterty of different sources of MSCs, support role for other cells, immunogenicity, immune regulation and their application.
METHODS: The relevant article published between March 2001 and March 2010 were searched for in PubMed database by computer with the key words “mesenchymal stem cells, tissue engineering” . Also searched related article in Wanfang Database with the key words of “mesenchymal stem cells, tissue engineering”. A total of 182 documents were retrieved.
RESULTS AND CONCLUSION: MSCs are derived from embryonic mesoderm, have the potential of multi-directional differentiation, and can be applied to tissue engineering. Moreover, MSCs provide support for cell growth, regulate immune state of the body, and have been extensively utilized in medical field. At present, the studies of MSCs function have achieved some successes, but these studies are at early stage and there are many theoretical and technical problems. Further studies are needed to determine how to effectively control the MSCs directional differentiation, proliferation, migration and integration in vivo and how to participate in host cell tissue function.

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