Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (36): 6805-6808.doi: 10.3969/j.issn.1673-8225.2010.36.035

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Inducement factors and signal transduction regulation in the osteogenic process of bone marrow mesenchymal stem cells    

Li Rui-dong, Huang Wei   

  1. Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing  400016, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Huang Wei, Doctor, Chief physician, Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China huangwei68@263.net
  • About author:Li Rui-dong★, Studying for master’s degree, Physician, Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China stab_lee@yahoo.com.cn

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) can be induced to differentiate into various cells under suitable conditions. In addition, BMSCs, with the characteristics of stromal cells, can secrete various cytokines, support hematopoietic function, and BMSCs are a source of ideal cells for tissue remodeling and function repair.
OBJECTIVE: To review various factors that can influence osteogenic process of BMSCs and common signal transduction pathway.
METHODS: A computer-based search was performed in PubMed database (1998-01/2009-05) with the key words of “bone mesenchymal stem cell, osteogenesis”. Vip database (1998-01/2009-05) was searched with the key words of “osteogenesis, bone morphogenetic protein, bone marrow mesenchymal stem cells”.
RESULTS AND CONCLUSION: A total of 108 articles concerning bone marrow mesenchymal stem cells and bone morphogenetic protein were retrieved, including 31 Chinese articles and 77 English articles. Those published earlier or with poor experimental design and with poor scientific evaluation were excluded, and finally 15 articles were included. Osteogenesis procedure of BMSCs mostly depends on the induced differentiation situation including the basic adjuvants, bone morphogenetic protein, some other cytokines and hormones. In addition, a series of signal pathways plays an important role in the control and interaction of this process. Heat shock protein is worthy of paying attention on affecting the process of proliferation, differentiation and the protective mechanism of signaling adjustment for stimulation outside BMSCs.

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