Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (36): 6809-6812.doi: 10.3969/j.issn.1673-8225.2010.36.036

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Regulatory mechanisms and influential factors of mesenchymal stem cell differentiation

Hua Yan-long, Li Cai-ping   

  1. Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot  010050, Inner Mongolia Autonomous Region, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Li Cai-ping, Professor, Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China licp_nfm@163.com
  • About author:Hua Yan-long★, Studying for master’s degree, Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China nmgyxhyl@163.com
  • Supported by:

    the Major Scientific Research Program of Hospital Affiliated to Inner Mongolia Medical College, No. NMFYZD2008003*

Abstract:

BACKGROUND: Along with the thorough understanding of mesenchyma stem cells (MSCs) that present widespread application in tissue engineering research. For example, the treatments of anemic cerebrovascular disease, body ischemia and so on.
OBJECTIVE: To understand the research progress of the ability of bone marrow mesenchymal stem cell (BMSC) differentiation.
METHODS: A computerized search through the PubMed database was undertaken from August 2003 to August 2009. The key words were “mesenchymal stem cell differentiation, Wnt, ß-catenin, bone morphogenetic protein, vascular endothelial growth factor”. Totally, 213 literatures were collected. Articles concerning regulatory mechanisms and influential factors of MSC differentiation were included;Repetitive studies and Meta analysis were excluded.Finally,15 articles were used for the review.
RESULTS AND CONCLUSION: With the development of bioengineering disciplines, people know more about the regulation of BMSCs differentiation and influential factors. Many factors found in the survival of MSC microenvironment such as bone morphogenetic protein and vascular endothelial growth factors, which play an important role in regulating cell differentiation. The external factors also play an important role, such as the membrane potential. MSC senescence may affect the ability of cell differentiation.

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