Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6389-6392.doi: 10.3969/j.issn.1673-8225.2010.34.029

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Vascularization of tissue engineered repair materials for damaged myocardium

Shen Nan 1,2, Shen Yang1, Liu Xiao-heng1   

  1. 1 Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu   610045, Sichuan Province, China; 2 School of Life Science, Sichuan University, Chengdu   610045, Sichuan Province, China 
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Liu Xiao-heng, Professor, Doctoral supervisor, Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610045, Sichuan Province, China liuxiaohg@sina.com.cn
  • About author:Shen Nan, Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610045, Sichuan Province, China; School of Life Science, Sichuan University, Chengdu 610045, Sichuan Province, China Nicolebio7@gmail.com

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Abstract:

BACKGROUND: Myocardium is weak in regenerating, making tissue engineering the top treatment after infarction. Thereby, vascularization plays a crucial role in the progress of repair.
OBJECTIVE: To summarize the research progress of tissue engineered repair for damaged myocardium from the perspectives of scaffold design, vascular growth factor delivery, in vivo prevascularization and in vitro prevascularization.
METHODS: Using “Vascularization; Myocardium; Tissue Engineering; Regeneration Medicine” as the key words, a computer research was performed in Sciencedirect database and Archive of Issues Nature database between January 1995 and April 2010. Totally 150 articles were screened out and 32 of them were involved in the analysis.
RESULTS AND CONCLUSION: The structure, composition and physical features of the scaffolds play a vital part in the process of vascularization, mainly expressed in the speed of vascularization, the integrity and function of new vessels. A variety of vascular growth factors serve various roles in different stages of the angiogenesis process. Current research shows that in vivo pre-vascularization is the most efficient, but patients have to bear second surgeries and some vascular loss. In vitro pre-vascularization provides graft tissues with central vessels, thus immediately realizing blood supply, but In vitro pre-vascularization requires high demand of the culture environment, which is difficult to meet in general hospitals. In addtion, it is necessary to establish a matrix without heterogeneous materials, preferably simulating in vivo micro-environment. Untile now, all models can only achieve micron-level thickness, leaving a long gap from the practical clinical therapy.

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