Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6247-6252.doi: 10.3969/j.issn.1673-8225.2010.33.041

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Association of Homocysteine and its metabolic enzyme genes polymorphisms with essential hypertension in Xinjiang Kazakhs

Wang Hong1, Wu Gui-zhen2, Zhang Ying1, Zhang Xiang-yang1, Chen Yu-lan1, Ai Si-kar3   

  1. 1 First Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uighur Autonomous Region, China; 2 Department of Biochemics, Basic Medical Medicine, Xinjiang Medical University, Urumqi  830054, Xinjiang Uighur Autonomous Region, China; 3 Department of Cardiology, Xinjiang People’ s Hospital, Urumqi  830054, Xinjiang Uighur Autonomous Region, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Zhang Xiang-yang, Chief physician, Professor, Doctoral supervisor, First Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China zxy12957@sina.com.cn
  • About author:Wang Hong☆, Doctor, Associate chief physician, First Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China hong001w@163.com

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Abstract:

BACKGROUND: The incidence of hypertension in Xinjiang Kazakhs belongs to front row in country, but the pathogenesis of hypertension remains poorly understood. It is reported and confirmed that Homocysteine (Hcy) has relation with many cardiovascular diseases, but there are still no reports whether the level of Hcy and gene polymorphism of Hcy metabolism-related enzymes exist relation with essential hypertension in Xinjiang Kazakhs.
OBJECTIVE: To investigate the relationship of homocysteine, methylenetetrahydrofolate reductase (MTHFR) A1298C, methionine synthase (MS) A2756G polymorphisms and essential hypertension in Xinjiang Kazakhs.
METHODS: A total of 408 Kazakhs subjects were divided into 2 groups: the hypertension group (n = 195), including 93 males and 102 females, average aged (49.44±9.71) years. Control group (n = 213), including 95 males and 118 females, mean aged (40.82±8.87) years. The gene polymorphisms of MTHFR A1298C and MS A2756G were measured by specific primer PCR and polymerase chain reaction-Restriction fragmentlength polymorphism (PCR-RFLP) method. The levels of plasma Hcy were measured using enzymoimmunoassay.
RESULTS AND CONCLUSION: The level of plasma Hcy were significantly higher in the hypertension group than that of the control group (P < 0.05), and there was significant difference in gender, the level of plasma Hcy in male was higher than that in female (P < 0.05). The distribution of genotypic and allelic frequencies had no significant difference between the hypertension group and the control group (P > 0.05). There were no significant difference in the level of plasma Hcy among subjects with the difference genotypes in MTHFR A1298C, MS A2756G and jointed genotypes in MTHFR A1298C and MS A2756G (P > 0.05). There was probably no relation between MTHFR A1298C and MS A2756G genetic polymorphism and essential hypertension in Xinjiang Kazakhs. Higher level of Hcy was probably a risk factor for hypertension in Xinjiang Kazakhs, but it was not an independent risk factor for hypertension in Xinjiang Kazakhs.

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