Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6121-6124.doi: 10.3969/j.issn.1673-8225.2010.33.010

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Establishment of a porcine acute myocardial infarction model using minimally invasive procedures

Tao Si-ming1, Guo Tao2, Pu Shun-hua1, Yu Zhuo2, Wang Yu2, Yang Chao2   

  1. 1 Department of Cardiology, Fourth Affiliated Hospital of Kunming Medical University, Second People’s Hospital of Yunnan Province, Kunming  650021, Yunnan Province, China; 2 Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming  650021, Yunnan Province, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Guo Tao, Master, Professor, Doctoral supervisor, Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China guotao20@hotmail.com
  • About author:Tao Si-ming☆, Doctor, Attending physician, Department of Cardiology, Fourth Affiliated Hospital of Kunming Medical University, Second People’s Hospital of Yunnan Province, Kunming 650021, Yunnan Province, China taosm6450@126.com
  • Supported by:

    the Social Tackle Program of Yunnan Province, No. 2006SG10*; the Social Development  Plan of Yunnan Province, No. 2008CD007*

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Abstract:

BACKGROUND: A sustained and stable model of cardiac ischemia is an important basis for angiogenesis research. Conventional “balloon transient dilation” has disadvantage of vascular recanalization after drawing balloon, it is hard to evaluate the therapeutic effect of angiogenesis.
OBJECTIVE: To explore a optimize method that could establish the porcine model of acute myocardial infraction safer, quicker, and more convenient than routine methods.
METHODS: Thirty healthy, adult pigs were randomly divided into 2 groups. Balloon transient dilation + plug implantation and directly plug implantation were used to construct myocardial infraction models. Intervention operation times and success rates were observed and compared between two groups.
RESULTS AND CONCLUSION: A total of 27 pigs underwent induction of myocardial infraction successfully. Success rate of balloon transient dilation + plug implantation group was 84.6%, and that of the directly plug implantation group was 94%, there was not statistic significant compared with two groups (P > 0.05). However, the mean operation time of the directly plug implantation group was shorter than that of the balloon transient dilation+ plug implantation group (P < 0.01). The myocardial infraction models prepared by directly plug implantation method are characterized by feasible, safe, and relatively effective, which can simulate procedure of clinical myocardial infraction.

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