Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (32): 6031-6035.doi: 10.3969/j.issn.1673-8225.2010.32.031

Previous Articles     Next Articles

Current research of differentiation from different sources-derived stem cells into neural cells

Zhuge Dong1, Liang Zhan-hua2, Song Lin1, Liu Jing1   

  1. 1 Center for Regenerative Medicine, 2 Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian  116011, Liaoning Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Liu Jing, Doctor, Professor, Center for Regenerative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
  • About author:Zhuge Dong★, Studying for master’s degree, Center for Regenerative Medicine, First Affiliated Hospital of Dalian Medical University; Dalian 116011, Liaoning Province, China zhugedong @ sohu.com
  • Supported by:

    the International Cooperation Program of Bureau of Science and Technology of Dalian City, No.2009F11GH179*

PDF

524

Abstract:

BACKGROUND: Refractory nervous system diseases, including degenerative diseases, stroke sequelae, brain and spinal cord injury, mainly present a large number of neuronal necrosis and loss of function. Adult mammalian central nervous system regeneration after injury is poor, almost impossible to generate new neurons, or to complete self-repair. The recovery of function in injured or degenerated brain tissue has not been able to solve. Stem cell research and application offered hope for patients with nervous system disease.
OBJECTIVE: Studies on stem cells have become a hot point in recent years. We are in attempt to search the relevant literature of the differentiation from different sources-derived stem cells into neural cells, and to compare the ability of differentiation from different sources-derived stem cells into neural cells.
METHODS: We searched for the related articles in PubMed published from January 1995 and December 2009 in recent five years. The key words were “neuronal differentiation, embryonic stem cells, bone marrow mesenchymal stem cells. adipose derived mesenchymal stem cells, peripheral blood stem cells, umbilical cord blood stem cells” in English. The articles were selected primarily and the attached literatures were looked through. The articles were related to differentiation from different sources-derived stem cells into neural cells.
RESULTS AND CONCLUSION: Ideal seed cells should be minimally invasive, easy to access, easy-to-amplify in vitro, do not involve the immune rejection of tumorigenicity and ethical issues. These advantages have not yet found in the seed cells. The ideal seed cells derived not only to consider the legal issues and more importantly, directed differentiation of cells. Ideal cells should be selected according to the ability of stem cells during stem cell transplantation in the nervous system. There are great differences in research outcomes concerning the ability of differentiation of stem cells into neural cells, so ideal seed cells cannot be identified. Future research needs to study the differentiation of stem cells from different sources into neural cells.

CLC Number: