Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (32): 6027-6030.doi: 10.3969/j.issn.1673-8225.2010.32.030

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Umbilical cord blood stem cells: New seed cells for the research of construction of tissue engineered artificial heart

Chen Gui-xiu1, Feng Bin2, Liu Tao1   

  1. 1 Department of Internal Cardiology, 2 Department of Thoracic & Cardiac Surgery, Second Clinical Medical College/Nanchong Central Hospital of North Sichuan Medical College, Nanchong  637000, Sichuan Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Feng Bin, Master’s supervisor, Department of Thoracic & Cardiac Surgery, Second Clinical Medical College/Nanchong Central Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China fsn9977@yahoo.com.cn
  • About author:Chen Gui-xiu★, Studying for master’s degree, Department of Internal Cardiology, Second Clinical Medical College/Nanchong Central Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China xiuxiu.19860102@163.com
  • Supported by:

    the Application Basic Research Foundation of Sichuan Province, No. 2008JY0689-1*

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Abstract:

BACKGROUND: Umbilical cord blood stem cells contain a variety of stem/progenitor cells. Usage of these stem/progenitor cells for transplantation therapy and as seed cells in tissue engineering research is a current research focus.
OBJECTIVE: To review the biological characteristics of various types of stem /progenitor cells contained in umbilical cord blood stem cells and related stem cell-based experimental application for treatment of heart diseases.
METHODS: To search related literatures by computer retrieval in China Hospital Knowledge Database and Chongqing VIP information web by using key words as “umbilical cord blood stem cell, hematopoietic progenitor/ stem cells, mesenchymal stem cells, endothelial progenitor cells, endothelial cells, myocardial cells, tissue engineering, seed cells” in Chinese from January 1999 to October 2009. Further literatures searching was tried in PubMed database with search terms limited to “umbilical cord blood stem cell, hematopoietic progenitor cells/hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, endothelial cells, myocardial cells, tissue engineering, seed cells” in English from January 1999 to October 2009. In addition, manual retrieval of the monograph of Stem Cell Biology was also done. A total of 95 documents were retrieved. According to the inclusion criteria, 30 documents were finally selected.
RESULTS AND CONCLUSION: Umbilical cord blood stem cells are a kind of adult multipotent stem cells, including hematopoietic progenitor cells/hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, unrestricted somatic stem cells and so on. Umbilical cord blood stem cells contain rich primitive stem cells, which have stronger differentiation and proliferation capacity, smaller rejection reaction and get more easily than that of bone marrow stem cells and peripheral blood stem cells. Umbilical cord blood stem cells can differentiate into many kinds of cells such as myocardial cells and vascular endothelial cells in vitro. Based on the unique biological characteristic and source superiority of umbilical cord blood stem cells, the outcome in treatment of coronary heart disease and ischemic cardiomyopathy had obtained. Umbilical cord blood stem cells may be a new source of seed cells for construction tissue engineered artificial heart, and show broad prospects for research of heart regeneration and tissue engineered artificial heart.

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