Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (32): 6022-6026.doi: 10.3969/j.issn.1673-8225.2010.32.029

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Application of vascular tissue engineered seed cells to regeneration medicine

Li Chun-min1, Wang Zhong-gao2   

  1. 1 Department of Vascular Surgery, Fuxing Hospital, Capital Medical University, Beijing 100038, China; 2 Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing  100053, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Wang Zhong-gao, Professor, Academician, Doctoral supervisor, Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China zhonggaowang@ yahoo.com
  • About author:Li Chun-min☆, Doctor, Attending physician, Department of Vascular Surgery, Fuxing Hospital, Capital Medical University, Beijing 100038, China
  • Supported by:

    the National High Technology Research and Development Programof China (“863” Program), No. 2006AA02A134*

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Abstract:

BACKGROUND: Small bore artificial vessels to substitute human body arteriole and vein have not obtained satisfactory outcomes. Thus, to develop a small bore artificial vessels with high long-term patency rate has been a key research program.
OBJECTIVE: To review the latest progress of seed cells in vascular tissue engineering. 
METHODS: A computer based search was conducted in Pubmed database for articles concerning vascular tissue engineered seed cells published from 1960 to 2009 with the key words of “vascular tissue engineering, seeding cells”. The literatures with simple design, poor reliability, non English or repetitive results were excluded. Finally, 35 articles were included for further use.
RESULTS AND CONCLUSION: The endothelial cells and smooth muscle cells were commonly used in the vascular tissue engineering. Endothelial cells and smooth muscle cells simulate in vivo environment to keep their normal secretory function and phenotype. Bone marrow mesenchyme stem cells can be effectively isolated and amplified, and can differentiate into various vascular cells under the special conditions and have strong potential in regeneration medicine and biological tissue engineering.

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