Abstract:

BACKGROUND: Refractory wound is difficult to treat using traditional methods in the clinic. Studies have shown that growth factor plays an important role in wound healing, and transgenic therapy is emerging to treat refractory wound. 
OBJECTIVE: To review the research status and progress of treating refractory wound by summarizing literatures concerning gene therapy.
METHODS: PubMed database was searched by the first author using key words of “gene therapy, burns, chronic wounds” for English papers published between January 1999 and December 2008. Documents with regard to refractory wound and gene therapy were included. Totally 33 literatures were analyzed. 
RESULTS AND CONCLUSION: According to sources of transfected cells, the transgenic technology can be divided into in vivo gene transfection and in vitro gene transfection. The in vivo gene transfection processes greater superiority than other methods. Though it can not be spread in clinical application, transgenic technology owns extensive prospect.