Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (20): 3779-3783.doi: 10.3969/j.issn.1673-8225.2012.20.038

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Meta-analysis on CDKAL1 gene rs7754860 single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility  

Wang Juan1, 2, Chen Li-ming3, Sun Hong-xi1, Guo Jun1, Wen Juan-juan1   

  1. 1Graduate School of Tianjin Medical University, Tianjin  300070, China; 2Department of Endocrinology, Tianjin Tianhe Hospital, Tianjin  300050, China; 3Department of Endocrinology, Metabolic Disease Hospital of Tianjin Medical University, Tianjin  300070, China
  • Received:2012-03-09 Revised:2012-03-15 Online:2012-05-13 Published:2012-05-13
  • Contact: Chen Li-ming, Doctor, Chief physician, Department of Endocrinology, Metabolic Disease Hospital of Tianjin Medical University, Tianjin 300070, China xfx22081@vip.163.com
  • About author:Wang Juan, Attending physician, Graduate School of Tianjin Medical University, Tianjin 300070, China; Department of Endocrinology, Tianjin Tianhe Hospital, Tianjin 300050, China wangjuan_th@163.com
  • Supported by:

     the National Natural Science Foundation of China, No. 81072922*

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Abstract:

BACKGROUND: The pathogenesis of type 2 diabetes is unclear, and genetic studies have shown that there may be genetic predisposition, but the results are not consistent with each other.
OBJECTIVE: To evaluate the relationship between cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene rs7754860 G<C single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility.
METHODS: By searching EMBSE (1974/2011-05), PubMed (1966/2011-05), CNKI (1994/2011-05) and CBM (1978/2011-05), we collected studies about CDKAL1 gene rs7754860 G<C single neucleotide polymorphisms and type 2 diabetes mellitus susceptibility. The odds ratios (OR) of variant allele of CDKAL1 gene rs7754860 was calculated by using Review Manager 5.0 software.
RESULTS AND CONCLUSION: A total of 19 03 cases and 22 560 controls were included in nine case-control studies. The risk for type 2 diabetes mellitus was higher in the CC group compared with GG group (OR=1.51, 95% confidence interval (CI): 1.24-1.84, P < 0.01); For the dominant genetic model, the risk for type 2 diabetes mellitus had no significant difference between the CC+GG group and GG group (OR=1.22, 95%CI: 0.95-1.56, P=0.12). For the recessive genetic model, the risk for type 2 diabetes mellitus in the CC group was significantly increased as compared with the GC+GG group (OR=1.61, 95%CI: 1.41-1.83, P < 0.01). CDKAL1 gene rs7754860 C<G single neucleotide polymorphisms has close relationship with type 2 diabetes mellitus susceptibility. People with C allele are susceptible to type 2 diabetes mellitus.

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