Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (19): 3588-3592.doi: 10.3969/j.issn.1673-8225.2012.19.033

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Research progress in spinal cord neural stem cell Niche

Liao Fa-xue, Zhang Hui, Yin Zong-sheng   

  1. Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei  230022, Anhui Province, China
  • Received:2012-02-02 Revised:2012-03-10 Online:2012-05-06 Published:2012-05-06
  • Contact: Yin Zong-sheng, M.D., Professor, Doctoral supervisor, Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China yinzongsheng@sina.com.cn
  • About author:Liao Fa-xue★, Studying for master’s degree, Second Department of Orthopedics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China liaofaxue@126.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30973026*; the Natural Science Foundation of Anhui Province, No. 1104060625*

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Abstract:

BACKGROUND: Spinal cord injury is a common orthopedic disease. A lot of work has been done to focus on neural stem cells for treating spinal cord injury. The effect of spinal cord neural stem cell Niche on neural stem cells has become a gradually increasing research area.
OBJECTIVE: To summarize the related research progress in spinal cord neural stem cell Niche.
METHODS: A computer-based online search of Pubmed (1980-01/2011-11) and CNKI (2003-01/2011-11) was performed for articles in English and Chinese respectively with the key words “neural stem cells, niche/microenvironment, spinal cord”. In addition, manual search was performed.
RESULTS AND CONCLUSION: A total of 483 articles were obtained, and finally 31 articles were included. The Niche provides a relatively stable microenvironment for survival, self-renewal and differentiation of spinal cord neural stem cells. After spinal cord injury, the change of Niche plays an important impact on the fate of spinal cord neural stem cells. Understanding the research progress of spinal cord neural stem cell Niche would provide a theoretical basis for treatment of spinal cord injury using neural stem cells.

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