Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (17): 3152-3155.doi: 10.3969/j.issn.1673-8225.2012.17.026

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Feasibility of contrast-enhanced magnetic resonance imaging in assessing the morphology of surrounding tissues around the surgical site in rat models of partial brain resection

Ge Yan-ming, Li Yao-wu, Xu Min, Sun Xi-he, Zhang Gui-hua, Xin Shun-bao, Liu Feng-jie, Dong Peng   

  1. Imaging Center of Affiliated Hospital of Weifang Medical College, Weifang  261031, Shandong Province, China
  • Received:2011-09-27 Revised:2011-10-23 Online:2012-04-22 Published:2012-04-22
  • Contact: Dong Peng, Associate professor, Imaging Center of Affiliated Hospital of Weifang Medical College, Weifang 261031, Shandong Province, China dongpeng01502@yahoo.com.cn
  • About author:Ge Yan-ming★, Master, Lecturer, Imaging Center of Affiliated Hospital of Weifang Medical College, Weifang 261031, Shandong Province, China
  • Supported by:

     the Natural Science Foundation of Shandong Province, No. ZR2010HM078*

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Abstract:

BACKGROUND: A series of pathological changes can occur in the normal brain tissues around the surgical site after brain tumor resection, leading to the difficult neuroimaging identification between the residual tumor-induced contrast enhancement and normal brain tissue enhancement.
OBJECTIVE: To establish rat models of partial brain resection and to evaluate the feasibility of contrast-enhanced magnetic resonance imaging (MRI) in assessing the morphology of surrounding tissues around the surgical site by using Micro23 coil.
METHODS: Eighteen rats were randomly divided into experimental group and control group. In the experimental group, a partial resection of the normal brain tissue was performed under aseptic conditions, and then, the rats were given contrast-enhanced MRI using Micro23 coil at 3 and 7 days postoperatively. There was no treatment in control group.
RESULTS AND CONCLUSION: The contrast-enhanced MRI findings showed that the surgical margin was clear at 3 and 7 days postoperatively and the occurrence rate of contrast enhancement of the brain tissues around the surgical site was 100% in the experimental group. Contrast enhancement occurred at 3 days postoperatively and became higher at 7 days postoperatively. The shape of the surgical margin on contrast enhancement images was line-shaped or circular corresponding to the cavity. The findings suggested that contrast-enhanced MRI by using Micro23 coil was feasible for the experimental rat models of partial brain resection and it could display the imaging features of surgical margin clearly
 

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