Abstract:

BACKGROUND: Cytochrome P450 2E1 gene (CYP2E1) is one of the important encoding genes in its enzyme system. There are many studies on the relationship between CYP2E1 polymorphism and colorectal cancer susceptibility. However the results have some difference.
OBJECTIVE: To explore the relationship between CYP2E1 PstI/RsaI single neucleotide polymorphism and colorectal cancer susceptibility.
METHODS: Studies on the relationship between CYP2E1 PstI/RsaI single neucleotide polymorphism and colorectal cancer susceptibility were obtained by searching EMBASE database, PubMed database, Ovid database, Highwire press database, CNKI database, CBM database and Wanfang database. The odds ratio (OR) of CYP2E1 allele of the case group and control group was taken as effective index. Fixed or random effect Meta-analysis model was used to calculate the combined OR.
RESULTS AND CONCLUSION: A total of 9 case-control studies containing 4 760 patients and 5 812 controls were included according to inclusion criteria. Evaluation of risk of rectal cancer in mutation homozygote when wild homozygote was used as reference: OR=1.24 (OR=1.24, 95% confidence interval (CI): 0.93-1.66, P=0.15); Evaluation of risk of rectal cancer in mutation homozygote when wild homozygote and mutation homozygote were used as reference: OR=1.26 (OR=0.94, 95%CI: 0.94-1.68, P=0.12); Evaluation of risk of rectal cancer in mutation homozygote and wild homozygote when wild homozygote was used as reference: OR=1.00 (OR=1.00, 95%CI: 0.90-1.12, P=0.97). Sub-group analysis: the studies were divided into Caucasian populations and East Asian populations; Only the Caucasian populations showed a relationship between CYP2E1 PstI/RsaI single neucleotide polymorphism and colorectal cancer susceptibility in the c2c2 VS c1c1 model (OR=2.67, 95%CI: 1.03-6.89, P=0.04). It is indicated that there is no close relationship between CYP2E1 PstI/RsaI single neucleotide polymorphism and colorectal cancer susceptibility except the Caucasian in c2c2 VS c1c1 model.