Abstract:

BACKGROUND: The mechanism of organ functional lesion cause by abdominal compartment syndrome (ACS) is unclear. The appropriate animal models should be established for the in-depth study of the pathogenesis and pathophysiology.
OBJECTIVE: To investigate the related issues you might encounter during the process, including the model preparation standard, method, animal selection and monitoring of abdominal pressure.
METHODS: The PubMed database and CNKI database from 1990 to 2011 were used to search the articles on ACS, abdominal high pressure and related animal model.
RESULTS AND CONCLUSION: A successful animal model of ACS should have to maintain the stability of intra-abdominal pressure, and can persist for some time. Meanwhile it should impact on the experimental results as little as possible. Therefore, the key is the measurement of the intra-abdominal pressure in intraperitoneal infusion of liquid of gas model as well as the maintenance of a stable pressure. Dynamic monitor of the abdominal pressure can not be preformed on the intraperitoneal infusion of liquid model, and the pressure fluctuations is significant; To compare with intraperitoneal infusion of liquid model, it is convenient to measure the intra-abdominal pressure on intraperitoneal infusion of gas model, and the utilization of electronic supply system to dynamic monitor the intra-abdominal pressure is desirable. The establishment of physical model is forward-looking experiment, but the existing physical models are needed to be improved.