Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 652-654.doi: 10.3969/j.issn.1673-8225.2012.05.022

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Embryotoxic effect of deguelin in zebrafish

Li Wen-hao1, Wu Xin-rong1, 2   

  1. 1College of Light Industry and Food Sciences, South China University of Technology, Guangzhou  510641, Guangdong Province, China; 2Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou  510010, Guangdong Province, China
  • Received:2011-09-30 Revised:2011-12-16 Online:2012-01-29 Published:2012-01-29
  • Contact: Wu Xin-rong, Doctor, Chief pharmacist, Master’s supervisor, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, Guangdong Province, China; Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China gzwxrong@yahoo.com.cn
  • About author:Li Wen-hao★, Studying for master’s degree, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, Guangdong Province, China lwh288@qq.com
  • Supported by:
    Natural Science Foundation of Guangdong, No.10251001002000000*
     

Abstract:

Embryotoxic effect of deguelin in zebrafish BACKGROUND: The establishment of antitumor drug deguelin model provides basis for the in vivo experiment.
OBJECTIVE: To investigate the influence of different concentrations of deguelin on zebrafish embryonic development.
METHODS: The zebrafish embryos were treated with different concentrations of deguelin. The changes of the phenotype were observed at 48 and 72 hours after postfertilization, and the hatching rate was counted at 72 hours after postfertilization.
RESULTS AND CONCLUSION: The development of embryo was remained under 0.1 μmol/L concentration of deguelin. The development of embryo was delayed at 0.2 μmol/L concentration of deguelin. 0.3 μmol/L concentration of deguelin could inhibit the development of embryo and cause death of the embryo. These results show that high concentration of deguelin leads to embryonic lethality, while low concentration of deguelin delays the embryonic development.

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