Analgesic effects of intraarticular cocktail versus intravenous parecoxib injection after total hip arthroplasty

doi:10.3969/j.issn.2095-4344.2014.09.003

Abstract

Abstract:

BACKGROUND: Intraarticular cocktail analgesic injection is a popular postoperative analgesia method and can effectively control postoperative pain and relieve side effects after total hip arthroplasty.
OBJECTIVE: To compare and assess the effectiveness and safety of intraarticular analgesic injection or intravenous injection of parecoxib after total hip arthroplasty.
METHODS: A total of 60 patients undergoing total hip arthroplasty were randomly assigned to: treatment group (intraarticular cocktail analgesic injection with morphine, bupivacaine, and compound betamethasone), and control group (intravenous injection of parecoxib). All patients received tramadol hydrochloride at 24 hours after replacement. Analgesic consumption, visual analog scale at rest and during activity, range of motion, and postoperative complication of patients in each group were recorded.
RESULTS AND CONCLUSION: Intraarticular cocktail analgesic injection significantly reduced analgesic consumption. When comparing visual analog scale scores, rest pain scores were significantly less in the treatment group at 12, 24 and 48 hours after replacement than that in the control group (P < 0.05). Scores on range of motion were significantly less in the treatment group at 24 and 36 hours than that in the control group(P < 0.05). No significant differences in total complications were detectable between the treatment and control groups (P > 0.05). Results suggested that intraarticular cocktail analgesic injection lessened analgesic consumption after replacement, relieved early pain after replacement, and contributed to early rehabilitation of patients. Moreover, no significant adverse reactions were visible.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

CLC Number:

R318

Du Xue-ping, Lu Jian-quan, Xu Ping, Zhu Yu-chang, Dong Da-yong. Analgesic effects of intraarticular cocktail versus intravenous parecoxib injection after total hip arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(9): 1325-1330.

Figures/Tables 4

2.4 置换后疼痛目测类比评分置换前关节内鸡尾酒注射治疗组与帕瑞昔布静脉注射对照组的目测类比评分分别为2.5±0.8及2.8±1.2，两者之间差异无显著性意义 (P > 0.05)。静息状态下关节内鸡尾酒注射治疗组患者置换后12，24，48 h及置换后3，7，14 d的目测类比评分依次为3.0±0.9，2.5±0.7，2.1±0.9，2.5±0.7，2.4±1.1及2.1±1.2分，而帕瑞昔布静脉注射对照组其置换后12，24，48 h及置换后3，7，14 d的目测类比评分则依次为4.4±1.8，3.8±2.1，3.6±1.5，2.6±0.9，2.3±1.3及2.5±1.1分，关节内鸡尾酒注射治疗组患者置换后12，24，48 h疼痛较帕瑞昔布静脉注射对照组有明显缓解 (P < 0.05)，而帕瑞昔布静脉注射对照组在置换后3，7，14 d疼痛程度虽较关节内鸡尾酒注射治疗组患者高，但二者之间差异无显著性意义(P > 0.05，表2)。置换前关节内鸡尾酒注射治疗组患者置换后12，24，48 h及置换后3，7，14 d活动时疼痛目测类比评分依次为4.6±1.6，3.6±1.5，3.0±1.2，3.2±0.9，3.1±1.2及3.0±1.6，而帕瑞昔布静脉注射对照组患者置换后12，24，48 h及置换后3，7，14 d活动时疼痛目测类比评分依次为5.9±2.1，4.2±0.7，4.0±1.2，3.6±1.5，3.4±1.6及2.9±1.9分，治疗组患者置换后12，48 h活动疼痛较对照组有明显优势(P < 0.05，表2)。 2.5 手术时间和住院时间比较关节内鸡尾酒注射治疗组和帕瑞昔布静脉注射对照组患者全髋置换从切皮到缝合结束的平均用时依次为(60.2±5.2) min及(55.2± 6.2) min，关节周围及关节腔内注射延长了手术时间，差异有显著性意义(P=0.001)。关节内鸡尾酒注射治疗组的住院时间为(10.4±2.1) d，帕瑞昔布静脉注射对照组的住院时间为(11.0±2.5) d，两组比较差异无显著性意义(P=0.318)。"

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