Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (52): 9813-9816.doi: 10.3969/j.issn.1673-8225.2011.52.028

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Variations of vascular endothelial dysfunction of the femoral head in diabetic rats

Zheng Yu-tao1, Chen Hai-ying1, Liu Wen-ge2, Zhang Peng-fei3   

  1. 1Department of Basic Medicine, Medical College of Putian University, Putian  351100, Fujian Province, China
    2Department of Orthopedics, Affiliated Union Hospital of Fujian Medical University, Fuzhou  350003, Fujian Province, China
    3Department of Pathology, Fujian Medical University, Fuzhou  350003, Fujian Province, China
  • Received:2011-10-18 Revised:2011-11-11 Online:2011-12-24 Published:2011-12-24
  • About author:Zheng Yu-tao, Associate professor, Department of Basic Medicine, Medical College of Putian University, Putian 351100, Fujian Province, China zheng_yu_tao@163.com
  • Supported by:

    Class A Science and Technology Foundation of Fujian Educational Department, No. JA08189*

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Abstract:

BACKGROUND: Onset reason of the complications of diabetic osteopathia is complicated. Endothelial lesions of blood vessel in bone tissue may play an important role in onset reason.
OBJECTIVE: To investigate the effects of diabetes on endothelial dysfunction of the femoral head in the rats.
METHODS: Totally 60 rats were randomly divided into diabetic group and control group. Diabetic model was constructed by intraperitoneal injection of streptozotocin in the diabetic group.
RESULTS AND CONCLUSION: Compared with the control group at 15 weeks after modeling, microstructure of the femoral head in the rats was changed, serum levels of nitric oxide level was significantly decreased, plasma endothelin 1 was significantly increased and expression of blood coagulation factorⅧ was significantly decreased in the diabetic group (P < 0.01). It is indicated that the endothelial dysfunction occurs in the prediabetes. Endothelial dysfunction is induced by micrangium accrementition and diabetes, which are related with the hypofunction of the femoral head in the rats.

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