Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (52): 9709-9712.doi: 10.3969/j.issn.1673-8225.2011.52.004

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A 2 Hz extremely low-frequency pulsed magnetic field promotes the healing of fresh limb fractures following metallic implants internal fixation

Liu Ji-tao, Tao Jun   

  1. First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang  330008, Jiangxi Province, China
  • Received:2011-07-05 Revised:2011-10-18 Online:2011-12-24 Published:2011-12-24
  • Contact: Tao jun, Associate professor, Associate chief physician, Master’s supervisor, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China taojun125@sohu.com
  • About author:Liu ji-tao★, Studying for master’s degree, Physician, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China bluceliu123@163.com
  • Supported by:

    Technology Program of Health Department of Jiangxi Province in 2009-2010, No. 20093164*

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Abstract:

BACKGROUND: Delayed bone healing and nonunion are prone to occur after fracture treated with internal fixation.
OBJECTIVE: To study the clinical effects of the pulsed magnetic fields (PEMFs) of different extremely low-frequency for treatment of fresh fracture of limbs after internal fixation with metallic implants.
METHODS: The patients with fresh fractures of the limbs were divided into four groups randomly. The patients of control group were treated with routine therapy and the patients of treatment group were treated with PEMFs of 2 Hz, 16 Hz and 32 Hz at 3 days after fixation. X-ray was performed at 4, 8, 12 weeks after fixation in all patients. The osteocalcin, bone-specific alkaline phosphatase and the carboxy-terminal propeptide of type Ⅰ procollagen were detected before and after fixation followed PEMFs to evaluate the effects of PEMFs on fracture.
RESULTS AND CONCLUSION: The callus formation of four groups were significantly higher than before as time going on (P <  0.01). The callus formation and biochemical indexes of bone metabolism of PEMFs groups of 2 Hz, 16 Hz and 32 Hz were significantly higher than that of the control group at the same time point (P < 0. 01), and the callus formation and biochemical indexes of bone metabolism of PEMFs group of 2 Hz were higher than those of the 16 Hz and 32 Hz (P < 0. 05). It is confirmed that PEMFs can promote the growth of callus to accelerate the healing process of bone fracture, and the effective of the extremely low-frequency PEMFs of 2 Hz is better than that of 16 Hz and 32 Hz.

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