Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9643-9647.doi: 10.3969/j.issn.1673-8225.2011.51.034

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Application and role of chitosan in tumor radiotherapy

Liu Bin1, 2, Zhang Bao-ping2, Zhang Hong1, Li Zhi-ge2, Pan Xiao-jing2   

  1. 1Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou  730000, Gansu Province, China
    2College of Stomatology, Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Received:2011-06-04 Revised:2011-07-18 Online:2011-12-17 Published:2011-12-17
  • Contact: Zhang Hong, Doctor, Researcher, Doctoral supervisor, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China zhangh@ impcas.ac.cn
  • About author:Liu Bin☆, Doctor, Professor, Master’s supervisor, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China; College of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • Supported by:

    State Key Development Program of Basic Research of China, No. 2010CB834202*; Major Program of National Natural Science Foundation of China, No. 10835011*; Major Project of Science and Technology of Gansu Province in 2007, No. O702NKDA045*; Major Project of Science and Technology of Gansu Province in 2008, No. 0801NKDA001*; Basic Research Fee for Central Universities, Lanzhou University in 2011, No. lzujbky-2011-134*

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Abstract:

BACKGROUND: Currently, the improvement in the effect of radiation therapy by sensitizer is one of the hotspot in tumor radiotherapy field. Chitosan has a good biocompatibility and biodegradability, and can be used as a kind of multi-functional sensitizer to apply in radiotherapy for synergy therapy.
OBJECTIVE: To summarize the research status, application principle and development of chitosan applied in tumor radiotherapy at home and abroad recently.
METHODS: A computer-based online search of literatures related to biological effect of chitosan published between 1995 and 2009 in CNKI database, VIP database, Wanfang database, China Biology Medicine disc, Elsevier database and PubMed database was performed. Totally 194 articles in Chinese and in English were collected. 48 of them were chosen to summarize according to inclusion criteria. The anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan were analyzed to summarize its radiosensitivity.
RESULTS AND CONCLUSION: Chitosan has been proved to be a kind of multi-functional sensitizer for radiotherapy by the experiments of the anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan.

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