Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9501-9504.doi: 10.3969/j.issn.1673-8225.2011.51.001

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In vitro degradation mechanism of beta-tricalcium phosphate/alpha-calcium sulfate hemihydrates bone graft

Li Peng1, Mao Ke-ya1, Jiang Tao2, Yang Yun2, Cui Fu-zhai3, Hou Xi-jun1, Liang Mao-hua1, Du Ming-kui1, Wang Ji-fang1, Wang Yan1   

  1. 1Department of Orthopedics, General Hospital of Chinese PLA, Beijing  100853, China
    2Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing  100853, China
    3Department of Materials Science and Engineering, Beijing  100853, China
  • Received:2011-06-15 Revised:2011-07-20 Online:2011-12-17 Published:2011-12-17
  • Contact: Ma Ke-ya, Doctor, Associate chief physician, Master’s supervisor, Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China
  • About author:Li Peng★, Studying for master’s degree, Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China lance_slee@ yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 50830102*; the National 863 Program of China, No. 2009AA02Z405*

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Abstract:

BACKGROUND: The ideal degradation rate of bone repair materials should be matched with the speed of new bone formation, and the bone repair materials are replaced by new bone gradually via creeping substitution.
OBJECTIVE: To investigate the in vitro degradation mechanism and degradation speed of β-tricalcium phosphate/α-calcium sulphate hemihydrates (β-TCP/α-CSH) bone graft.
METHODS: β-TCP/α-CSH, β-TCP and α-CSH samples were soaked in PBS liquid. The pH value, degradation rate and compressive stress were examined.
RESULTS AND CONCLUSION: In the PBS liquid, the pH value of β-TCP/α-CSH bone graft and α-CSH gradually decreased with the soaked time, but that of β-TCP changed little. After 4 weeks, the pH value of β-TCP/α-CSH bone graft and α-CSH was stabilized to about 5.6. The weight and compressive stress of β-TCP/α-CSH bone graft and α-CSH were gradually decreased with the soaked time in the PBS liquid, but those of β-TCP decreased little. β-TCP/α-CSH bone graft can gradually degrade through physical dissolution in vitro, and the degradation rate is lower than that of β-TCP but higher than that of α-CSH.

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