Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9496-9500.doi: 10.3969/j.issn.1673-8225.2011.50.045

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Relations between the expression level of FOXC2 mRNA in ventral adipose tissue and type 2 diabetes

Nian Xin1, Wei Jun-jie2, Su Yan-dan3, Liu Hua3, Zhang Xu-xiang1, Li Hong1   

  1. 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China; 2Department of Inspection, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, Yunnan Province, China; 3Clinical Genetic Laboratory, Department of Inspection, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • Received:2011-06-03 Revised:2011-10-19 Online:2011-12-10 Published:2011-12-10
  • Contact: Su Yan-dan, Technician-in-charge, Clinical Genetic Laboratory, Department of Inspection, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China lh197306@sohu.com
  • About author:Nian Xin★, Master, Attending physician, Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China nianxinkm@hotmail.com
  • Supported by:

     the Education Department of Yunnan Province in 2005, No. 5y0336*

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Abstract:

BACKGROUND: FOXC2 is closely related to the differentiation of adipose cells. It plays an important role in many aspects, such as energy metabolism, resistance of type II diabetes and metabolic syndrome.
OBJECTIVE: To investigate the expression level of FOXC2 mRNA in human ventral adipose tissue of Yunnan Province, and to explore the relations between FOXC2 and type II diabetes.
METHODS: Type II diabetic patients or nondiabetic patients underwent abdominal surgery in Affiliated Hospital of Kunming Medical University were randomly selected as experimental subjects, with 50 cases in each group. The expression level of FOXC2 mRNA in ventral adipose tissue was detected by RT-PCR. The correlation of FOXC2 mRNA expression and subject clinical data was analyzed.
RESULTS AND CONCLUSION: The expression level of FOXC2 mRNA in ventral adipose tissue in type II diabetic patients decreased. The FOXC2 mRNA expression level of diabetic group was inversely related to fasting blood-glucose and blood pressure. The FOXC2 mRNA expression level of nondiabetic group was inversely related to fasting blood-glucose. These findings indicate that FOXC2 may reduce insulin resistance and improve the regulation of insulin on sugar metabolism in type II diabetic patients. In addition, the decrease of FOXC2 expression shows a synergetic effect on blood press raise in diabetic patients.

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