Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (46): 8714-8717.doi: 10.3969/j.issn.1673-8225.2011.46.039

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Role of transforming growth factor beta 2 in cartilage formation

Yang Yue1, Xue Tong-yuan1, Tian Jing2   

  1. 1Second Clinical Medical College of Southern Medical University, Guangzhou  510515, Guangdong Province, China
    2Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Received:2011-08-24 Revised:2011-10-15 Online:2011-11-12 Published:2011-11-12
  • Contact: Tian Jing, Professor, Master's supervisor, Associate chief physician, Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China Tian_jing6723@yahoo.com.cn
  • About author:Yang Yue, Second Clinical Medical College of Southern Medical University, Guangzhou 510515, Guangdong Province, China yysunmoon522@hotmail.com

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Abstract:

BACKGROUND: Transforming growth factor β2 is a family of polypeptide growth factors with multiple biological effects. It plays a role in the proliferation and differentiation of mesenchymal stem cells. It is one of the most important regulation factors for the mesenchymal stem cell proliferation and differentiation into cartilage cells.
OBJECTIVE: To analyze the molecular structure of transforming growth factor β2 and its role in cartilage formation.
METHODS: An online search of CNKI, VIP and PubMed database was performed for relevant articles on transforming growth factor β2 and cartilage formation of bone tissue engineering published between January 1995 and August 2011, using key words of " TGF-β2; cartilage formation; tissue engineering" in Chinese and English, respectively. Articles on the induction of chondrocyte differentiation, treatment progress of cartilage diseases, molecular structure and signal transduction pathway of transforming growth factor β2 were included. Duplicated studies, antiquated standpoint or review literatures were excluded.
RESULTS AND CONCLUSION: A total of 302 articles were obtained in the initial search. According to inclusion criteria, 262 of them were excluded, 40 documents were finally selected. Analysis results show that transforming growth factor β2 can facilitate the synthesis of cartilage specific matrix, such as type II collagen and proteoglycan, by promoting the differentiation from mesenchymal stem cell to chondrocyte. Therefore, transforming growth factor β2 has an induction effect on cartilage. It regulates the proliferation and differentiation of chondrocyte with other growth factors, which makes it possible to permanently repair the cartilage defects in the clinic.

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