Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8133-8136.doi: 10.3969/j.issn.1673-8225.2011.43.037

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Aseptic loosening after prosthetic replacement

Tan Wei-qin, Yang Shi-jun, Cui Jian-he   

  1. Department of Nuclear Medicine, First People’s Hospital of Huaian, Nanjing Medical University, Huaian  223300, Jiangsu Province, China
  • Received:2011-08-11 Revised:2011-08-16 Online:2011-10-22 Published:2011-10-22
  • About author:Tan Wei-qin, Associate chief physician, Department of Nuclear Medicine, First People’s Hospital of Huaian, Nanjing Medical University, Huaian 223300, Jiangsu Province, China 1123406537@qq.com

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Abstract:

BACKGROUND: Aseptic loosening after total hip replacement has been a trouble for the surgeons.
OBJECTIVE: To investigate the mechanism, influential factors and prevention measures of prosthetic loosening.
METHODS: A computer based search of CNKI and PubMed (1993-01/2010-11) was performed for articles about the mechanism, influential factors and prevention measures of prosthetic loosening using the keywords of “Prosthetic loosening, Mechanism, Factors, Treatment” in Chinese and English. Repetitive and Meta analysis articles were excluded.
RESULTS AND CONCLUSION: Finally, 21 articles were included in the result analysis. After artificial joint replacement, the wear debris particles on the implant-bone interface and surrounding bone tissues can induce a series of biological reactions through the interaction. It is the key to cause aseptic loosening. However, the aseptic loosening can be improved by the improvement of prosthesis design and materials as well as promotion of implanting skill and reasonable prevention.

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