Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8046-8049.doi: 10.3969/j.issn.1673-8225.2011.43.017

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Biomechanical characteristics of medial collateral ligaments in animal models of knee osteoarthritis

Jin Xiao-fei1, 2, Guo Chang-qing1, Jiang Zhao-xia1, Liu Fu-shui1, 3   

  1. 1Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing  100029, China
    2Department of Acupuncture and Moxibustion, Shanxi University of Traditional Chinese Medicine, Taiyuan  030024, Shanxi Province, China
    3Jiangxi University of Traditional Chinese Medicine, Nanchang  330004, Jiangxi Province, China
  • Received:2011-04-15 Revised:2011-08-24 Online:2011-10-22 Published:2011-10-22
  • Contact: Guo Chang-qing, Professor, Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing 100029, China
  • About author:Jin Xiao-fei★, Master, Lecturer, Acupuncture and Moxibustion School, Beijing University of Chinese Medicine, Beijing 100029, China; Department of Acupuncture and Moxibustion, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China 47355033@qq.com

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Abstract:

BACKGROUND: Factors of mechanics and physical chemistry lead to degeneration of cartilage matrix which may cause knee osteoarthritis (KOA). There are lot of studies on factors of physical chemistry and degeneration of cartilage matrix and few studies on factors of mechanics.
OBJECTIVE: To explore the change of tension for medial collateral ligament (MCL) of rabbit KOA models.
METHODS: Rabbits in the model group were copied into KOA models, after which test on tension was performed to each of the 6 rabbits in the two groups at the speed of 5 mm/min on Bose Electro Force 3300 protracted test machine. Data obtained from the test every 0.1 s were recorded as far as the sample was pulled and broken.
RESULTS AND CONCLUSION: Maximum displacement, maximum stress, maximum strain and modulus of elasticity of MCL were (2.76±0.37) mm, (17.92±3.18) MPa, (10.7±2.07)%, (316.19±74.55) MPa in the normal control group and (2.08±0.31) mm, (11.34±1.05) MPa, (7.97±1.65)%, (279.77±33.91) MPa in the model group. We could see that each index in the normal control group was greater than that in the model group obviously (P < 0.05). It indicates that KOA has a certain effect on the biomechanics of MCL.

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