Abstract:

BACKGROUND: Vascular endothelial cell injury, slow blood flow, hypercoagulability, and abnormal white blood cell rheology are the important factors for deep vein thrombosis after joint replacement.
OBJECTIVE: To analyze the association of serum interleukin 6, 8, 10, C-reactive protein expression with deep vein thrombosis after joint replacement.
METHODS: Serum interleukin 6, 8, 10, C-reactive protein expression were detected 68 cases of joint replacement patients before and after replacement, and ultrasonic testing was used to determine whether deep vein thrombosis occurred.
RESULTS AND CONCLUSION: The expression of serum interleukin 6, 8, 10, C-reactive protein in thrombosis patients after joint replacement was higher than that of patients without thrombosis after joint replacement at 1 and 3 days (P < 0.05), indicating inflammatory factors participated in thrombosis formation. Real-time monitoring of changes in these indicators could help to prevent thrombosis. In the patients with thrombosis, the levels of serum interleukin 6, 8, 10, C-reactive protein were higher at 1 and 3 days after joint replacement than before joint replacement (P < 0.05); however, at 5 days after joint replacement, the levels of these indicators were close to those before joint replacement (P> 0.05). After joint replacement, the blood hypercoagulability had a gradual reduction process, especially at 3 days after joint replacement that was a key to anti-inflammatory anticoagulant treatment.