Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8031-8033.doi: 10.3969/j.issn.1673-8225.2011.43.013

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Expression of serum interleukin-6, 8, 10, C-reactive protein and deep vein thrombosis after joint replacement

Yang Feng, Sui Fu-ge, Zhang Yong, Li Heng, Ma Dong-sheng, Li Qiang, Tian Fei-peng   

  1. Fourth Ward, Department of Orthopedics, Longnan Hospital of Daqing, Daqing  163453, Heilongjiang Province, China
  • Received:2011-07-05 Revised:2011-08-16 Online:2011-10-22 Published:2011-10-22
  • About author:Yang Feng★, Master, Attending physician, Fourth Ward, Department of Orthopedics, Longnan Hospital of Daqing, Daqing 163453, Heilongjiang Province, China yangfeng1271030@163.com

Abstract:

BACKGROUND: Vascular endothelial cell injury, slow blood flow, hypercoagulability, and abnormal white blood cell rheology are the important factors for deep vein thrombosis after joint replacement.
OBJECTIVE: To analyze the association of serum interleukin 6, 8, 10, C-reactive protein expression with deep vein thrombosis after joint replacement.
METHODS: Serum interleukin 6, 8, 10, C-reactive protein expression were detected 68 cases of joint replacement patients before and after replacement, and ultrasonic testing was used to determine whether deep vein thrombosis occurred.
RESULTS AND CONCLUSION: The expression of serum interleukin 6, 8, 10, C-reactive protein in thrombosis patients after joint replacement was higher than that of patients without thrombosis after joint replacement at 1 and 3 days (P < 0.05), indicating inflammatory factors participated in thrombosis formation. Real-time monitoring of changes in these indicators could help to prevent thrombosis. In the patients with thrombosis, the levels of serum interleukin 6, 8, 10, C-reactive protein were higher at 1 and 3 days after joint replacement than before joint replacement (P < 0.05); however, at 5 days after joint replacement, the levels of these indicators were close to those before joint replacement (P> 0.05). After joint replacement, the blood hypercoagulability had a gradual reduction process, especially at 3 days after joint replacement that was a key to anti-inflammatory anticoagulant treatment.

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