Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (38): 7045-7048.doi: 10.3969/j.issn.1673-8225.2011.38.004

Previous Articles     Next Articles

Preparation and properties of porous co-substituted calcium polyphosphate scaffold as bone repair material

Jing Qi-fei2, Zhang Xu1, Xie Hui-xu3, Wang Qi-guang1, Zhang Xiao-hua1, Yu Xi-xun1, Wan Chang-xiu1   

  1. 1College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China
    2College of Materials Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China
    3 West China College of Stomatology，Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-05-03 Revised:2011-06-01 Online:2011-09-17 Published:2011-09-17
  • Contact: Wan Chang-xiu, Professor, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China wanchangxiu@163.com
  • About author:Jing Qi-fei, College of Materials Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China jingqifei525@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30870614*

PDF

420

Abstract:

BACKGROUND: Ions doping is an important method for the modification of bioceramic.
OBJECTIVE: To evaluate a novel co-substituted bioceramic scaffolds as bone repair material.
METHODS: The microstructure and crystallization of the scaffolds were detected by scanning electron microscope and X-ray diffraction. Compression strength test, degradation test and cell culture experiment were assumed to evaluate the properties of KSCPP in vitro. After a short period of muscle pouches implantation, the performance of KSCPP in vivo was evaluated.
RESULTS AND CONCLUSION: The results show that KSCPP scaffold has a higher compressive strength and degradation rate. Moreover, the MTT assay and implantation test reveal that the KSCPP scaffold exhibits lower cytotoxicity and better tissue biocompatibility than CPP and HA. The study proved the great potential of KSCPP in bone repair applications.

CLC Number: