Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (29): 5395-5398.doi: 10.3969/j.issn.1673-8225.2010.29.019

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Preparation and surface morphology analysis of submicron nano-hydroxyapatite/poly L-lactic acid composites

Du Jiang-hua 1,2, Li Dan1, Han Feng-lan1, Yang Qing-fang2   

  1. 1 Materials Science & Engineering College, North University for Nationalities, Yinchuan  750021, Ningxia Hui Autonomous Region, China; 2 Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an  710072, Shaanxi Province, China
  • Online:2010-07-16 Published:2010-07-16
  • Contact: Yang Qing-fang, Professor, Doctoral supervisor, Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an 710072, Shaanxi Province, China nwpudjh@sina.com.cn
  • About author:Du Jiang-hua☆, Studying for doctorate, Lecturer, Materials Science & Engineering College, North University for Nationalities, Yinchuan 750021, Ningxia Hui Autonomous Region, China; Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an 710072, Shaanxi Province, China nwpudjh@sina.com
  • Supported by:

     a Grant from North University for Nationalities, No. 2007Y042*

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Abstract:

BACKGROUND: Nano-hydroxyapatite (HA)/poly L-lactic acid (PLLA) composites as scaffold material in bone tissue engineering have good biocompatibility. However, HA is characterized by easy agglomeration and hard equably dispersed in materials, the combination between inorganic particle and organic high polymer is affected. 
OBJECTIVE: To prepare HA/PLLA composite, and study the effect of PLLA solution, the disperser time of HA, the content of HA on dispersion, and analyze the surface appearance, the cross section and the interface of HA/PLLA composites.
METHODS: Sub-micron HA/PLLA composites was prepared by the method of the solution blending, submicron HA powder was dispersed into the chloroform solution of PLLA with the aid of the ultrasonic wave, and then the mixed system was dried under the natural condition to remove the solvent, finally the submicron HA/PLLA compound materials was obtained. The effect of the solution concentration on dispersion HA in solution was discussed. The cross section of composites and interface were analyzed by the Fourier transform infrared spectroscopy and the scanning electron microscopy.
RESULTS AND CONCLUSION: When the mass ratio of sub-micron HA to PLLA was 0.15: 1 and dispersing time HA in PLLA solution exceeded 30 minutes. PLLA solution 0.14 kg/L can make HA good dispersity in PLLA. When sub-micron HA content exceeds 15%, it will produce reunion in composite materials. Infrared analysis shows that characteristic functional groups from HA/PLLA composites have no change. The results suggest that: sub-micron HA can be mixed well with PLLA by ultrasonic oscillation, which would improve the interface of sub-micron HA/PLLA composites.

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