Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (23): 4333-4336.doi: 10.3969/j.issn.1673-8225.2010.23.034

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New direction of acute tubular necrosis treatment: Mechanism of promoting kidney repair by exogenous mesenchymal stem cells

Liu Lin1,2, Cai Guang-yan1, Zhang Li1   

  1. 1Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing  100853, China;
    2Medical College, Nankai University, Tianjin  300071, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Cai Guang-yan, Chief physician, Professor, Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing 100853, China caiguangyan@sina. com
  • About author:Liu Lin, Master, Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing 100853, China; Medical College, Nankai University, Tianjin 300071, China yummylynn@126. com
  • Supported by:

    the Scientific Research Program of Medical Science of Chinese PLA during the 11th Five-Year Plan Period, No. 06Q065*

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Abstract:

BACKGROUND: Mesenchymal stem cells have become a spotlight in the field of tissue repair and regeneration, due to its extensive capacity of differentiation and secretion as well as simple collection, culture advantages and stable characteristics. In the field of nephrology, the ability of exogenous mesenchymal stem cells to promote the repair process following acute tubular necrosis has been proved in multiple animal researches. Meanwhile, researchers are making efforts to explore the exact mechanism.

OBJECTIVE: To review current animal researches about exogenous mesenchymal stem cells on promoting the repair process of acute tubular necrosis, and to analyze the results to further elucidate the mechanism of this promoting effect.

METHODS: We checked PubMed database about the related articles published from January 2004 to July 2009 on computer with key words of “mesenchymal stem cell, acute tubular necrosis, acute kidney injury, immune, cytokine, renal progenitor cells, tubular epithelial cells”. The language was limited to English. Simultaneously, we also checked the book Chinese Journal of Nephrology by hand. A total of 309 articles have been attained, with 306 from computer and 3 from the book, and 37 articles were consistent with inclusion criteria.

RESULTS AND CONCLUSION: In the field of nephrology, a great number of animal researches have proved that exogenous mesenchymal stem cells could promote the repair process after acute tubular necrosis, which provides a prospective effect for the treatment of acute tubular necrosis. Up to now, the possible mechanisms of this process include: ①mesenchymal stem cells differentiate into tubular epithelial cells directly to renew the damaged structure. ②Mesenchymal stem cells modulate immune system and activate intrinsic kidney cells via endocrine or paracrine to help repair the injured tissue.

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