Mechanism of spontaneous resorption in lumbar disc herniation and new strategies for precision treatment

doi:10.12307/2026.431

Abstract

Abstract: BACKGROUND: Lumbar disc herniation is a prevalent spinal degenerative disorder in clinical practice. Traditional treatment predominantly relies on surgical intervention; however, the phenomenon of spontaneous resorption in lumbar disc herniation offers a novel non-surgical approach.
OBJECTIVE: To investigate the efficacy of a comprehensive non-surgical treatment regimen in promoting the spontaneous resorption of a severely herniated L5/S1
disc through a two-year follow-up observation of a single patient, as well as to elucidate the mechanisms underlying disc spontaneous resorption and identify key indicators predictive of resorption potential.
METHODS: A single patient with severe L5/S1 disc herniation was selected and treated with a comprehensive non-surgical approach comprising non-steroidal anti-inflammatory drugs, physical therapy, and exercise rehabilitation. The patient was followed up for 2 years, during which changes in pain symptoms were closely monitored, and serial MRI examinations were conducted to dynamically record the evolution of the herniated material. Extensive literature review was also performed to deeply analyze the potential mechanisms of disc spontaneous resorption.
RESULTS AND CONCLUSION: After 2 years of comprehensive non-surgical treatment, the patient's pain symptoms significantly improved, with a marked reduction in the Visual Analogue Scale score. Magnetic resonance imaging clearly showed gradual resorption of the herniated material, confirming the therapeutic efficacy in promoting spontaneous resorption. The spontaneous resorption of the disc was found to be mediated by a coordinated biological process involving inflammatory response activation and neovascularization. Key indicators predictive of resorption potential were identified, including the characteristics of the herniated material, magnetic resonance imaging edge enhancement signs, and the status of the posterior longitudinal ligament. Furthermore, future research could leverage single-cell sequencing, multimodal imaging, and deep learning technologies to elucidate molecular mechanisms, realize early prediction, and assist in precise clinical treatment. In summary, this comprehensive non-surgical treatment regimen provides a reliable foundation for the management of lumbar disc herniation. The elucidation of multi-mechanism synergy clarifies the principles of resorption, while key predictive indicators facilitate the development of personalized treatment plans. The application of cutting-edge technologies points the way toward transforming the treatment of lumbar disc herniation into precise biotherapy and enhancing clinical outcomes.

Key words: lumbar disc herniation, spontaneous resorption, non-surgical management, conservative treatment, case report

CLC Number:

Aikeremujiang·Muheremu, Aikebaierjiang·Aisaiti, Alimujiang·Abudurousuli, Kutiluke·Shoukeer, Sala Yiding·Aierxiding, Abuduwupuer·Tailaiti, Abudunaibi·Aili, Jia Zhiwei. Mechanism of spontaneous resorption in lumbar disc herniation and new strategies for precision treatment[J]. Chinese Journal of Tissue Engineering Research, 2026, 30(35): 9135-9142.

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