Chinese Journal of Tissue Engineering Research ›› 2025, Vol. 29 ›› Issue (7): 1457-1465.doi: 10.12307/2025.015

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Bibliometric analysis of research process and current situation of brain aging and exosomes

Lyu Liting1, 2, Yu Xia3, Zhang Jinmei4, Gao Qiaojing1, Liu Renfan1, Li Meng1, Wang Lu1   

  1. 1School of Sports Medicine and Health, Chengdu Sports Institute, Chengdu 610041, Sichuan Province, China; 2Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (Affiliated Hospital of University of Electronic Science and Technology of China), Medical Genetics Center, Chengdu 610072, Sichuan Province, China; 3Department of Clinical Laboratory, Women’s and Children’s Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China/ Chengdu Women’s and Children’s Hospital, Chengdu 610091, Sichuan Province, China; 4Chaohu Institute, Hefei 238024, Anhui Province, China 
  • Received:2023-11-27 Accepted:2024-02-05 Online:2025-03-08 Published:2024-06-27
  • Contact: Wang Lu, MD, Professor, School of Sports Medicine and Health, Chengdu Sports Institute, Chengdu 610041, Sichuan Province, China
  • About author:Lyu Liting, Master, School of Sports Medicine and Health, Chengdu Sports Institute, Chengdu 610041, Sichuan Province, China; Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (Affiliated Hospital of University of Electronic Science and Technology of China), Medical Genetics Center, Chengdu 610072, Sichuan Province, China. Yu Xia, MD, Associate chief technician, Department of Clinical Laboratory, Women’s and Children’s Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China/ Chengdu Women’s and Children’s Hospital, Chengdu 610091, Sichuan Province, China. Lyu Liting and Yu Xia contributed equally to this article.
  • Supported by:
    Sichuan Provincial Key Laboratory of Sports Medicine or State General Administration of Sport Key Laboratory of Sports Medicine Project, No. 2022-A044 (to WL); National Natural Science Foundation of China (Youth Project), No. 31900848 (to WL); Youth Project of Science and Technology Department of Sichuan Province, No. 2022NSFSC1724 (to WL); Institute of Sports Medicine and Health, Chengdu University of Physical Education/Zheng Huaixian Bone Injury Research Institute 2021-2022 Innovation Project Funding, No. CX21B05/CX21C09 (to WL) 

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Abstract: BACKGROUND: In recent years, with the rapid development of biomedicine, the study of brain aging and exosomes has attracted more and more attention, but there is no bibliometrics analysis in this field. 
OBJECTIVE: To objectively analyze domestic and foreign literature on brain aging and exosomes in the past 15 years, to summarize the research status, hot spots, and development trends in this field. 
METHODS: Using the core database of Web of Science as a search platform, we downloaded the literature on brain aging and exosomes published from the establishment of the database to December 28, 2022, and analyzed the data from the aspects of country or region, institution, author, keywords, and co-cited literature using CiteSpace 6.1.R6 visualization software.
RESULTS AND CONCLUSION: A total of 1 045 research articles were included, and the number of publications on brain aging and exosomes research both domestically and internationally was showing an increasing trend year by year. The United States ranked first with 429 papers, and China ranked second with 277 papers. Louisiana State University ranked first with 16 articles. Professor Lukiw Walter J from Louisiana State University in the United States was the author with the highest number of publications, and Professor Bartel DP from the Massachusetts Institute of Technology was the author with the most citations. The most prolific Journal was the International Journal of Molecular Sciences. Alzheimer’s disease, microRNA, gene expression, extracellular vesicles, exosomes, oxidative stress, and biomarkers are the most relevant terms. According to the research on hot topics, biomarkers have become a new research hotspot. The above results indicate that the research on brain aging and exosomes has gradually increased in the past 15 years. The research direction has gradually shifted from the initial exploration of the expression of miRNAs in central nervous system diseases related to brain aging to the search for biomarkers that can identify and diagnose neurodegenerative diseases. The study of exocrine miRNAs to protect central nervous system from damage has emerged as promising therapeutic strategy.

Key words: brain aging, exosome, microRNA, CiteSpace, bibliometric analysis, central nervous system 

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