Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (12): 1869-1873.doi: 10.3969/j.issn.2095-4344.3774

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Safety of reducing nausea and vomiting by intravenous infusion of tropisetron hydrochloride after internal fixation with proximal femoral nail antirotation

Chen Sheng1, Zheng Zhihui2, Guan Keli2, Li Xiaowu2, Cai Peibiao2, Chen Haibo2, Zheng Xun2, Zeng Qingqiang2   

  1. 1Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China; 2Department of Orthopedics, Shantou Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shantou 515031, Guangdong Province, China
  • Received:2020-05-30 Revised:2020-06-02 Accepted:2020-07-09 Online:2021-04-28 Published:2020-12-25
  • Contact: Zeng Qingqiang, Master, Chief physician, Department of Orthopedics, Shantou Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shantou 515031, Guangdong Province, China
  • About author:Chen Sheng, Master candidate, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China Zheng Zhihui, Master, Associate chief physician, Department of Orthopedics, Shantou Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shantou 515031, Guangdong Province, China Chen Sheng and Zheng Zhihui contributed equally to this article.

Abstract: BACKGROUND: Tropisetron hydrochloride has been shown to effectively reduce postoperative nausea and vomiting in patients undergoing proximal femoral nail antirotation fixation, and it is safe and effective. At present, the use of tropisetron in this operation is mainly added to patient controlled intravenous analgesia or intravenous drip after the operation. However, the comparison of two administration methods of tropisetron is rarely reported. 
OBJECTIVE: To investigate the effectiveness and safety of different administration methods of tropisetron hydrochloride for reduction of postoperative nausea and vomiting in proximal femoral nail antirotation.
METHODS: Ninety patients with intertrochanteric fracture of femur who underwent proximal femoral nail antirotation admitted in Shantou Hospital of Traditional Chinese Medicine from July 2018 to March 2020 were randomly divided into two groups (n=45). Patients in the group A (intravenous drip administration group) were given tropisetron hydrochloride 5 mg + normal saline 100 mL by intravenous drip immediately after the operation, and the patient controlled intravenous analgesia pump (tropisetron hydrochloride was not added into the pump) was used. Patients in the group B (patient controlled intravenous analgesia pump group) were given 100 mL normal saline by intravenous drip immediately after the operation, and the patient controlled intravenous analgesia pump (5 mg tropisetron hydrochloride was added into the pump) was used. The pain score, sedative score, postoperative nausea and vomiting score and postoperative nausea and vomiting incidence at 1, 6, 12, 24, and 48 hours after the operation of two groups were counted and compared.  
RESULTS AND CONCLUSION: (1) The pain score and sedative score of the two groups were not statistically significant (P > 0.05) at various time points. (2) The postoperative nausea and vomiting score and postoperative nausea and vomiting incidence of group A were significantly less than those in the group B at 1 and 6 hours after the operation (P < 0.05). The differences in postoperative nausea and vomiting score and postoperative nausea and vomiting incidence of the two groups were not statistically significant at 12, 24, and 48 hours after the operation (P > 0.05). (3) There was no significant difference in incidence of adverse reactions between the two groups (P > 0.05). (4) Compared with added tropisetron hydrochloride to patient controlled intravenous analgesia pump, postoperative intravenous drip administration of tropisetron hydrochloride can quickly reduce the occurrence of nausea and vomiting after proximal femoral nail antirotation fixation. 


Key words: bone, femur, intertrochanteric fracture, tropisetron, proximal femoral nail antirotation, internal fixation, postoperative nausea and vomiting, pain, sedation

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