Abstract:

BACKGROUND: The new type Palindrome H-heparin-coated dialysis catheter is supposed to reduce the incidence of catheter-related infection and catheter dysfunction. However, the effect of this new type catheter on the systemic coagulation function is little reported.

OBJECTIVE: To evaluate the effects of the new type heparin-coated dialysis catheter of Palindrome H on the systemic coagulation function in hemodialysis patients.

METHODS: Patients who underwent maintenance hemodialysis and could not establish internal fistula at Blood Purification Center of the First People's Hospital of Foshan from January 2014 to June 2016 were enrolled. All participants were divided into Palindrome H heparin-coated and Permcath noncoated groups depending on the catheter type. The blood platelet count, prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombin time and fibrinogen degradation products were detected and compared between two groups. The study was approved by the Ethics Committee of the First People’s Hospital of Foshan, approval No. L[2014]5.

RESULTS AND CONCLUSION: Sixty patients were involved in the study (28 patients used the Palindrome H heparin-coated catheter and 32 patients used Permcath noncoated catheter). All patients were followed up for 30 months. The final measurement outcome was the average value at 0, 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30 months after surgery. No significant difference was found in the blood platelet count, prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombin time or fibrinogen degradation products between two groups (P > 0.05). No heparin induced thrombocytopenia was observed in all participants. Therefore, in clinical practice, the new type Palindrome H-heparin-coated dialysis catheters makes no effect on the systemic coagulation function compared with noncoated catheter.

Key words: hemodialysis, heparin-coated, Palindrome H catheter, vascular access, systemic coagulation function