Chinese Journal of Tissue Engineering Research ›› 2019, Vol. 23 ›› Issue (23): 3754-3759.doi: 10.3969/j.issn.2095-4344.1324

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Dextrose prolotherapy induces the proliferation of new cells to repair soft tissue and to alleviate pain: current status and problems

Yang Dan, Zhou Jing   

  1.  (Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China)
  • Received:2019-03-23 Online:2019-08-18 Published:2019-08-18
  • Contact: Zhou Jing, Master, Associate chief physician, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China
  • About author:Yang Dan, Master candidate, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China

Abstract:

BACKGROUND: Dextrose prolotherapy is a pain management method that injects a proliferation agent to induce the proliferation of new cells to repair soft tissue at the site where the tendon and ligament are attached to the bone tissue. Due to its low price and high safety, clinical applications are gradually increasing.
OBJECTIVE: To summarize the concept of hyperosmotic glucose hyperplasia therapy, current mechanism research, clinical research, matters needing attention, contraindications, side effects and adverse reactions.
METHODS: Keywords of “hypertonic glucose, dextrose prolotherapy and proliferation therapy” in English and Chinese were used in PubMed, Embase, The Cochrane Library, CNKI, VIP and WanFang databases. The articles related to the characteristics, generation and development of hypertonic glucose hyperplasia therapy were retrieved and summarized.
RESULTS AND CONCLUSION: Related cell studies and animal experiments have investigated the role of hypertonic glucose in promoting cartilage repair, profibrosis, and neurovascular effects. Clinical studies have shown that dextrose prolotherapy can treat many types of soft tissue injury and pain-like diseases, but the current experimental research mechanism is relatively simple, clinical trials are heterogeneous, and the follow-up time is short, so a lot of scientific studies on experimental mechanism still need to be carried out to clarify its specific mechanisms. High-quality, high homogeneity, long-term follow-up randomized controlled trials should be conducted to verify the clinical efficacy of dextrose prolotherapy.

Key words: hypertonic glucose, dextrose prolotherapy, proliferation therapy, soft tissue repair, pain, cartilage repair, research progress

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