Silicon-doped nano-hydroxyapatite: solubility, anti-fracture and compressive strengths

doi:10.3969/j.issn.2095-4344.2016.03.024

Abstract

Abstract:

BACKGROUND: Silicon-doped nano-hydroxyapatite has good biocompatibility and bioactivity, and has broad application prospect as a new biological material.
OBJECTIVE: To summarize the preparation process, principle, method of silicon-doped nano-hydroxyapatite and the effect of different doping methods on the solubility, surface morphology and the in vitro and in vivo biological effects of hydroxyapatite.
METHODS: The first author searched China National Knowledge Infrastructure (1990-2015), and Medline database (1990-2015) for related articles using the key words of “silicon, nano-hydroxyapatite, biological material,
biology, tissue engineering, bone repair” in Chinese and English, respectively.
RESULTS AND CONCLUSION: The preparation methods of silicon-doped nano-hydroxyapatite can be divided into two kinds: liquid phase method and solid phase method. Silicon doping can increase the solubility, anti-fracture and compressive strengths of nano-hydroxyapatite, and promote the osteogenesis of nano-hydroxyapatite, but the effects of different doping methods and specific gravity on the hydroxyapatite are different. Further research screening and optimization are still needed.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Cheng Yao, Wang Xing-xing, Wang Da-lin. Silicon-doped nano-hydroxyapatite: solubility, anti-fracture and compressive strengths[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(3): 435-440.

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