Application of intelligent hydrogels in bone regeneration and repair

doi:10.3969/j.issn.2095-4344.2016.03.023

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (3): 430-434.doi: 10.3969/j.issn.2095-4344.2016.03.023

Previous Articles Next Articles

Application of intelligent hydrogels in bone regeneration and repair

Yang Ling¹, Guan Xiao-yan^{1, 2}, Chen Li-ming³, Liu Jian-guo^{1, 2}

¹School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; ²the Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563099, Guizhou Province, China; ³Guiyang Stomatological Hospital, Guiyang 550002, Guizhou Province, China

Online:2016-01-15 Published:2016-01-15
Contact: Liu Jian-guo, M.D., Professor, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; the Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563099, Guizhou Province, China
About author:Yang Lin, Master, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China
Supported by:
the Scientific Innovation Talent Team Fund of Guizhou Province, No. [2013]4026; the Key Discipline Construction Project of Higher Education in Guizhou Province, No. SZXK-201207-04; the Special Key Laboratory Building Project of Higher Education in Guizhou Province, No. KY[2013]109; Joint Fund of Science and Technology Department of Guizhou Province, No. SY-J[2012]47; Scientific Cooperation Project of Guizhou Province and Zunyi City, No. [2014]41

Abstract

Abstract:

BACKGROUND: Intelligent hydrogel as a new material is widely used in biological medicine, tissue engineering, memory element switch, biological enzyme immobilization and other related fields, and exhibits good biological characteristics. Intelligent hydrogels provide a new approach for regeneration and repair of bone and other hard tissues.
OBJECTIVE: To summarize the latest developments of intelligent hydrogel in the biological medicine and tissue engineering in order to find out new methods for regeneration and repair of bone and other hard tissues.
METHODS: A computer-based research of CNKI, PubMed and EBSCO-MEDLINE databases was performed to retrieve relevant literatures about the application of intelligent hydrogel in regeneration and repair of bone and other hard tissues published from 2000 to 2015. The keywords were “hydrogel, bone tissue engineering, bone defect, regeneration, repair” in Chinese and English, respectively.
RESULTS AND CONCLUSION: Intelligent hydrogels are classified into pH-sensitive, temperature-sensitive, light-sensitive, multiple-sensitive and other sensitive hydrogels. In order to improve the mineralization ability of the hydrogel and construct the three-dimensional polymer scaffold of hydrogel, the main structure of the hydrogel materials can be mixed with various signal factors, thus achieving the multi-utility and multi-function of the material system, which will become the development trend of tissue engineering construction.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Yang Ling, Guan Xiao-yan, Chen Li-ming, Liu Jian-guo. Application of intelligent hydrogels in bone regeneration and repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(3): 430-434.

References

[1] Bajpai AK, Shukla SK, Bhanu S, et al. Responsive Polymers In Controlled Drug Delivery. Prog Polymer Sci. 2008;33(11): 1088-1118.

[2] Hamley IW, Cheng G, Castelletto V. A Thermoresponsive Hydrogel Based on Telechelic PEG End-Capped with Hydrophobic Dipeptides. Macromol Biosci. 2011; 11(8): 1068-1078.

[3] Ma Z, Yang C, Song W, et al. Chitosan hydrogel as siRNA vector for prolonged gene silencing. Nanobiotechnology. 2014;19:12-23.

[4] Kim JK, Yoo C, Cha YH, et al. Thermo-reversible injectable gel based on enzymatically-chopped low molecular weight methylcellulose for exenatide and FGF21 delivery to treat types 1 and 2 diabetes .J Control Release J.Control Release, 2014;194:316-322.

[5] Nanda J,Biswas A,Banerjee A. Singleamino acid based thixotropic hydrogel formation and pH-dependent morphological change of gel nanofibers.Soft Matter. 2013; (9):4198-4208.

[6] Cheng E, Xing Y, Chen P, et al. A pH-triggered, fast-responding DNA hydrogel. Angew Chem Int Ed Engl. 2009;48(41): 7660-7663.

[7] Tsurkan MV, Wetzel R, Perez-Hernandez HR, et al. Photopatterning of Multifunctional Hydrogels to Direct Adult Neural Precursor Cells.Adv Healthc Mater. 2015; 4(4): 516-521.

[8] Cai Z, Zhang JT, Xue F, et al. 2D photonic crystal protein hydrogel coulometer for sensing serum albumin ligand binding. Anal Chem.2014;86(10): 4840-4847.

[9] Cho YI, Park S, Jeong SY, et al. In vivo and in vitro anti-cancer activity of thermo-sensitive and photo-crosslinkable doxorubicin hydrogels composed of chitosan-doxorubicin conjugates. Eur J Phar Biopharm. 2009;73(1): 59-65.

[10] Wu Z, Lin X, Zou X, et al.Biodegradable protein-based rockets for drug transportation and light-triggered release. ACS Appl Mater Interfaces. 2015;7(1):250-255.

[11] Gkioni K, Leeuwenburgh SC, Douglas TE, et al. Mineralization of hydrogels for bone regeneration. Tissue Eng Part B Rev.2010;16(6):577-585.

[12] Phadke A, Zhang C, Hwang Y, et al. Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. Biomacromolecules. 2010;11(8): 2060-2068.

[13] 杜大江,刘真,邵林,等. 构建仿生解剖外形的个体化人工骨的新方法[J].哈尔滨医科大学学报,2014,48(3):195-201.

[14] 任迅, 姚静, 杜芹,等. 通过自生长方式实现壳聚糖—胶原聚合物引导的牙体硬组织仿生再矿化[J]. 华西口腔医学杂志, 2014, 32(5):519-524.

[15] Annabi N,Nichol JW,Zhong X, et al. Controlling the porosity and microarchitecture of hydrogels for tissue engineering .Tissue Eng Part B Rev. 2010;16(4):371-383.

[16] Street J, Bao M, deGuzman L, et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA. 2002;99:9656-9661.

[17] Park S, Kim G, Jeon YC, et al. 3D polycaprolactone scaffolds with controlled pore structure using a rapid prototyping system.Mater Sci Mater Med.2009;20:229-234.

[18] Taboas JM, Maddox RD, Krebsbach PH, et al. Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. Biomaterials . 2003;24(1):181-194.

[19] Battistella E, Varoni E, Cochis A, et al. Degradable polymers may improve dental practice. Appl Biomater Biomech. 2011;9: 223-231.

[20] Draghi L, Resta S, Pirozzolo MG, et al. Microspheres leaching for scaffold porosity control. Mater Sci Mater Med. 2005; 16 (12):1093-1097.

[21] 孟昊业,郑裕东,奚廷斐,等. 复合多孔水凝胶的微观结构与数字散斑相关分析[J]. 复合材料学报,2011,28(1):50-55.

[22] Huang GY, Zhou LH, Zhang QC, et al. Microfluidic hydrogels for tissue engineering. Biofabrication.2011;3(1):98-106.

[23] 金郁葱.大豆蛋白凝胶结构和质构的控制研究[D].华南理工大学, 2013.

[24] 何显运.医用功能性可降解聚氨酯复合体系构建的研究[D].华南理工大学,2012.

[25] Moshaverinia A,Chen C,Xu X,et al. Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold .Tissue Engi. Part A.2014;20(3-4): 611-621.

[26] Sun B,Ma W,Su F,Wang Y,et al. The osteogenic differentiation of dog bone marrow mesenchymal stem cells in a thermo-sensitive injectable chitosan/ collagen/ beta-glycerophosphate hydrogel: in vitro and in vivo. Mater Sci Mater Med. 2011; 22 (9): 2111-2118.

[27] 叶辰,李振华,李丹,等. 聚富马酸丙二醇酯/羟基磷灰石复合多孔水凝胶的制备及其矿化性能研究[J].高分子学报, 2012,56(10):1143- 1150.

Application of intelligent hydrogels in bone regeneration and repair

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 0

Recommended Articles

Metrics

Comments