Polyvinyl alcohol hydration algae salt bubble wound dressings with sealing negative pressure drainage repair diabetic foot ulcers

doi:10.3969/j.issn.2095-4344.2015.52.018

Abstract

Abstract:

BACKGROUND: Biological dressings with sealing negative pressure drainage can promote the healing of acute and chronic wounds.

OBJECTIVE: To observe the clinical effects of biological dressings with sealing negative pressure drainage in repair of diabetic foot ulcer.

METHODS: Totally 40 patients with diabetic foot ulcer were enrolled and all underwent debridement or debridement plus skin grafting treatment. Wound treatment methods were selected according to the willing of patients. Patients in the test group (n=20) underwent polyvinyl alcohol hydration algae salt bubble wound dressings with sealing negative pressure drainage. Patients in the control group (n=20) underwent regular wound dressing treatment. At the 7^th day of repair, visual analog scale scores, blood sedimentation, C-reactive protein levels, wound healing time, patient satisfaction and economic costs at the termination of the treatment in these two groups were compared.

RESULTS AND CONCLUSION: The visual analog scale scores, blood sedimentation, C-reactive protein levels in the test group were lower than those in the control group (P < 0.05). The wound healing time in the test group was shorter than that in the control group (P < 0.05), and the patient satisfaction was higher in the test group than the control group (P < 0.05). There was no significant difference in economic costs between the two groups. There was no local or systemic toxicity, allergy and other adverse reactions in the test group. These results demonstrate that polyvinyl alcohol hydration algae salt bubble wound dressings with sealing negative pressure drainage in repair of diabetic foot ulcer is safe and effective to promote wound healing and reduce local inflammatory response.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

CLC Number:

R318

Zhou Juan, Chen Xiao-yun, Yu Hong-mei. Polyvinyl alcohol hydration algae salt bubble wound dressings with sealing negative pressure drainage repair diabetic foot ulcers[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(52): 8461-8466.

Figures/Tables 7

References

[1] Federer AE,Haughom BD,Levy DM,et al.Blastomyces Tenosynovitis of the Foot and Ankle: A Case Report and Review of the Literature.J Foot Ankle Surg.2015.pii: S1067-2516(15)00177-5.

[2] Avrahami R,Rosenblum J, Gazes M,et al.The Effect of Combined Ultrasound and Electric Field Stimulation on Wound Healing in Chronic Ulcerations.Wounds. 2015;27(7): 199-208.

[3] Hegewald KW,Wilder ML,Chappell TM,et al.Combined Internal and External Fixation for Diabetic Charcot Reconstruction: A Retrospective Case Series.J Foot Ankle Surg. 2015. pii: S1067-2516(15)00179-9.

[4] Desman E,Bartow W,Anderson LH.Human Skin Allograft for Patients With Diabetic Foot Ulcers, Venous Leg Ulcers, or Surgical/Traumatic Wounds Retrospective, Descriptive Study.Ostomy Wound Manage. 2015;61(7):16-22.

[5] Crawford F,Cezard G,Chappell FM,et al.A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS).Health Technol Assess.2015;19(57): 1-210.

[6] Armstrong DG,Hurwitz BL, ipsky BA.Set Phages to Stun: Reducing the Virulence of Staphylococcus aureus in Diabetic Foot Ulcers.Diabetes.2015;64(8):2701-2703.

[7] Huang ET,Mansouri J,Murad MH,et al.A clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers.Undersea Hyperb Med. 2015;42(3):205-247.

[8] Huang E.Adjunctive hyperbaric oxygen therapy for diabetic foot ulcers: An editorial perspective.Undersea Hyperb Med. 2015;42(3):177-181.

[9] Delea S,Buckley C,Hanrahan A,et al.Management of diabetic foot disease and amputation in the Irish health system: a qualitative study of patients' attitudes and experiences with health services.BMC Health Serv Res.2015;15:251.

[10] Langer V,Bhandari PS,Rajagopalan S,et al.Negative pressure wound therapy as an adjunct in healing of chronic wounds.Int Wound J.2015;12(4):436-442.

[11] Qu J,Yan R,Wang L,et al.Free dermatoplasty combined with vacuum sealing drainage for the treatment of large-area soft tissue defects accompanied by bone exposure in the lower leg.Exp Ther Med.2013;5(5):1375-1380.

[12] Yang YH,Jeng SF,Hsieh CH,et al.Vacuum-assisted closure for complicated wounds in head and neck region after reconstruction.J Plast Reconstr Aesthet Surg. 2013;66(8): e209-216.

[13] Liu L,Tan G,Luan F,et al.The use of external fixation combined with vacuum sealing drainage to treat open comminuted fractures of tibia in the Wenchuan earthquake.Int Orthop.2012; 36(7):1441-1447.

[14] Beno M,Martin J,Hatzl J.Vacuum sealing in the treatment and prevention of prosthetic infections--a case review.Rozhl Chir. 2010;89(8):508-512.

[15] Moch D,Fleischmann W,Russ M.The BMW (biosurgical mechanical wound treatment) in diabetic foot.Zentralbl Chir.1999;124 Suppl 1:69-72.

[16] Lazzarini PA,O'Rourke SR,Russell AW,et al.Reduced Incidence of Foot-Related Hospitalisation and Amputation amongst Persons with Diabetes in Queensland, Australia. PLoS One.2015;10(6):e0130609.

[17] Shaked G,Czeiger D,Abu Arar A,et al.Intermittent cycles of remote ischemic preconditioning augment diabetic foot ulcer healing.Wound Repair Regen. 2015;23(2):191-196.

[18] Lew EJ,Mills JL Sr,Armstrong DG.The deteriorating DFU: prioritising risk factors to avoid amputation.J Wound Care. 2015;24(5 Suppl 2):31-37.

[19] Chadwick P,McCardle J.Assessing infected ulcers: a step-by-step guide.J Wound Care.2015;24(5 Suppl 2):15-19.

[20] Shi B,Sun J,Cao Y,et al.Application of vacuum sealing drainage to the treatment of seawater-immersed blast-injury wounds.Int Wound J.2015.doi: 10.1111/iwj.12444.

[21] Wang J,Zhang H,Wang S.Application of vacuum sealing drainage in the treatment of internal fixation instrument exposure after early postoperative infection.Minerva Chir. 2015;70(1):17-22.

[22] Tang J, Guo WC, Yu L,et al.Clinical efficacy of artificial skin combined with vacuum sealing drainage in treating large-area skin defects.Chin J Traumatol. 2010;13(5):289-292.

[23] Sermoneta D,Di Mugno M,Spada PL,et al.Intra-abdominal vacuum-assisted closure (VAC) after necrosectomy for acute necrotising pancreatitis: preliminary experience.Int Wound J. 2010;7(6):525-530.

[24] Williams ML, Holewinski JE.Use of a human acellular dermal wound matrix in patients with complex wounds and comorbidities.J Wound Care.2015;24(6):261-262,264-267.

[25] Ruppert V.Commentary on 'Strategies for Free Flap Transfer and Revascularisation with 10 Year Outcome in the Treatment of Large Diabetic Foot Lesions'.Eur J Vasc Endovasc Surg. 2015;50(2):231.

[26] Wu L, Hou Q, Zhou Q,et al.Prevalence of risk factors for diabetic foot complications in a Chinese tertiary hospital.Int J Clin Exp Med.2015;8(3):3785-3792.

[27] Chiwanga FS, Njelekela MA.Diabetic foot: prevalence, knowledge, and foot self-care practices among diabetic patients in Dar es Salaam, Tanzania - a cross-sectional study. J Foot Ankle Res.2015;8:20.

[28] Ghaderian SB,Hayati F,Shayanpour S,et al.Diabetes and end-stage renal disease; a review article on new concepts.J Renal Inj Prev.2015;4(2):28-33.

[29] Rankin TM,Miller JD,Gruessner AC,et al.Illustration of Cost Saving Implications of Lower Extremity Nerve Decompression to Prevent Recurrence of Diabetic Foot Ulceration.J Diabetes Sci Technol.2015;9(4):873-880.

[30] Rerkasem K,Kosachunhanun N,Sony K,et al. Underrecognized Peripheral Arterial Disease in Patients With Diabetes Mellitus in Thailand: We Must Consider Neuroischemic Foot Ulcers From This Fallout.Int J Low Extrem Wounds.2015;14(2):132-135.

[31] Butt DA,Hester T,Bilal A,et al.The medial column Synthes Midfoot Fusion Bolt is associated with unacceptable rates of failure in corrective fusion for Charcot deformity: Results from a consecutive case series.Bone Joint J.2015;97-B(6):809-813.

[32] Rodgers KE,Bolton LL,Verco S,et al. NorLeu<sup>3</sup> -Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers.Adv Wound Care (New Rochelle). 2015; 4(6):339-345.

[33] Harindhanavudhi T,Parks A,Mauer M,et al.Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients. Am J Nephrol.2015;41(4-5):277-283.

[34] Marx RC,Mizel MS.What's New in Foot and Ankle Surgery.J Bone Joint Surg Am. 2015;97(10):862-868.

[35] Caruana L,Formosa C,Cassar K.Prediction of wound healing after minor amputations of the diabetic foot.J Diabetes Complications.2015;29(6):834-837.