Biodegradable materials combined with osteogenic factor in orthopaedics

doi:10.3969/j.issn.2095-4344.2015.52.021

Abstract

Abstract:

BACKGROUND: Biodegradable implants cannot only rebuild bone defect site, moreover, with the gradual degradation of the materials, new bone tissue can completely replace the graft materials to fill bone defects.

OBJECTIVE: To summarize the research progress of biodegradable materials combined with osteogenic factor in orthopedics.

METHODS: We took the “biodegradable materials, factors, cell active factor, bone tissue engineering” as the search terms in Chinese and English, respectively, to retrieve the related literatures from PubMed, Wanfang and CNKI database during 2000 to 2015 by computer.

RESULTS AND CONCLUSION: Biodegradable medical polymer materials can be divided into natural polymer materials and synthetic biodegradable materials. Natural polymeric materials have good biocompatibility, but poor mechanical strength. The mechanical strength of synthetic biodegradable materials is higher than that of natural polymer materials, but the synthetic biodegradable materials are likely to cause local accumulation of acidic substances, produce local inflammation. The biodegradable medical polymer materials combined with osteogenic factor can improve the mechanical strength and osteoinductive ability of materials, but as a bone repair material, it still has many problems to be solved.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

CLC Number:

R318

Liu Da-hai, Li Kai-nan, Wei You-hua. Biodegradable materials combined with osteogenic factor in orthopaedics [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(52): 8480-8486.

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