Autologous bone marrow stem cell transplantation for thromboangiitis obliterans: 5-year follow-up

doi:10.3969/j.issn.2095-4344.2015.23.015

Abstract

Abstract:

BACKGROUND: The assessment for long-term efficacy of chronic ischemic disease is more important than the short-term efficacy assessment, which associates with patient’s long-term quality of life and long-term survival rate.
OBJECTIVE: To observe the 5-year follow-up outcomes of autologous bone marrow stem cell transplantation for the treatment of thromboangiitis obliterans.
METHODS: This study enrolled 43 patients of thromboangiitis obliterans who underwent autologous bone marrow stem cell transplantation from August 2007 to January 2010 in the Department of Thyroid Vascular Surgery, the First Affiliated Hospital of Xinjiang Medical University. At 1, 2, 3, 4 and 5 years after transplantation, pain, cold sensation, and intermittent claudication distance were followed up by telephone; changes in limb ulcers were observed. At 1 year after transplantation, venous oxygen partial pressure and oxygen saturation of limbs were reviewed.
RESULTS AND CONCLUSION: A total of 38 thromboangiitis obliterans patients with complete follow-up data were included in the final analysis. Compared to the preoperation, pain, cold sensation, and intermittent
claudication significantly improved. The difference was statistically significant (Z values: -4.277, -5.086, -3.574,
P < 0.001). Compared with 1-5 years after operation, pain and cold sensation had no statistically difference (P > 0.05). Intermittent claudication distance had increased. Differences in terms of intermittent claudication distance was statistically significant (Z=43.898, P < 0.001). Significant differences in venous oxygen partial pressure and oxygen saturation were detected between preoperation and 1-year posttransplantation (t values: 36.790, 43.964, P values: 0.040, 0.037). Above results suggest that autologous bone marrow stem cell transplantation for thromboangiitis obliterans obtained stable long-term outcomes.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Myeloid Progenitor Cells, Transplantation, Autologous, Thromboangiitis, Obliterans, Treatment Outcome

CLC Number:

R394.2

Bai Chao, Guo Chen-ming, Luo Jun. Autologous bone marrow stem cell transplantation for thromboangiitis obliterans: 5-year follow-up[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(23): 3692-3697.

Figures/Tables 5

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