Umbilical cord blood neural stem cells for obsolete spinal cord injury

doi:10.3969/j.issn.2095-4344.2014.41.021

Abstract

Abstract:

BACKGROUND: With the medical development, prognostic outcomes of spinal cord injuries have not been improved significantly, and most patients also suffer from severe complications. Nowadays, lots of laboratories and clinical researches have suggested that cell therapy has a great potential, especially the application of umbilical cord blood stem cells in nervous system diseases.

OBJECTIVE: To explore the feasibility and clinical effect of umbilical cord blood neural stem cells transplantation for patients with obsolete spinal cord injury.

METHODS: Umbilical cord blood was harvested from newborns under aseptic condition, and differentiated into neural stem cells in vitro that were prepared into cell suspension at a concentration of 10⁹/L. The cell suspension (3 mL) was injected via the L₃_-₄ or L₄_-₅ into the subarachnoid space. American Spinal Injury Association (ASIA) scores and the residual urine were assessed before and 3 months after transplantation.

RESULTS AND CONCLUSION: After transplantation, all the patients showed a stable life indication. Three months later, ASIA scores were increased and the residual urine decreased, which significantly differed from those before transplantation (P < 0.05). These findings indicate that umbilical cord blood neural stem cells transplantation is a new treatment that can improve the limb function and life quality of patients with obsolete spinal cord injury.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: spinal cord injuries, neural stem cells, fetal blood, treatment outcome

CLC Number:

R394.2

Wu Yue-kui, Wang Shang-wu, Ma Jian-hua, Yi Bo, Gao Bing-bing, Qin Jia-zhen, Yang Zhi-jun, Dai Yi-wu. Umbilical cord blood neural stem cells for obsolete spinal cord injury [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(41): 6678-6683.

Figures/Tables 3

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