Chinese Journal of Tissue Engineering Research ›› 2025, Vol. 29 ›› Issue (35): 7544-7551.doi: 10.12307/2025.955

Previous Articles     Next Articles

Correlation of echocardiographic parameters with disability at 3 months after acute ischemic stroke

Yang Bo, Pan Xinfang, Chang Liuhui, Ni Yong   

  1. Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
  • Received:2024-10-22 Accepted:2024-12-23 Online:2025-12-18 Published:2025-04-30
  • Contact: Ni Yong, MD, Associate chief physician, Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
  • About author:Yang Bo, MD, Attending physician, Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 81601147 (to YB); Suzhou Heath Young Key Talents "National Tutorial System" Training Project, No. Qngg2024006 (to YB); Suzhou Applied Basic Research (Healthcare) Science and Technology Innovation Youth Project, No. SYW2024082 (to YB)

PDF

96

Abstract: BACKGROUND: Transthoracic echocardiography and speckle tracking echocardiography parameters are closely related to stroke occurrence and prognosis. However, the role of transthoracic echocardiography and three-dimensional speckle tracking echocardiography parameters in predicting functional disability following acute ischemic stroke remains unclear.
OBJECTIVE: To explore the relationship between transthoracic echocardiography and three-dimensional speckle tracking echocardiography parameters and functional disability at 3 months post-stroke in patients with acute ischemic stroke.
METHODS: A total of 299 patients with acute ischemic stroke admitted to the Second Affiliated Hospital of Soochow University between December 2020 and September 2022 were prospectively enrolled. Patients were divided into no disability (n=207) and disability (n=92) groups based on modified Rankin Scale (mRS) scores (≤ 1 as no disability; 1 < mRS score ≤ 5 as disability) at 3 months. Baseline characteristics and transthoracic echocardiography and three-dimensional speckle tracking echocardiography parameters were compared between groups. Independent risk factors for disability were identified using multivariate logistic regression. Predictive models were developed by incorporating variables associated with poor prognosis, and their performance was assessed using the receiver operating characteristic curve analysis. The optimal cutoff value for left ventricular ejection fraction was determined from the receiver operating characteristic curve, and patients were stratified into high and low left ventricular ejection fraction groups. Chi-square test was used to compare prognosis rate between two groups.
RESULTS AND CONCLUSION: (1) The disability group had significantly lower left ventricular ejection fraction compared with the no disability group (P=0.011). Significant differences in the National Institute of Health Stroke Scale scores, Trial of ORG 10172 in Acute Stroke Treatment, and Oxfordshire Community Stroke Project classifications were observed (P < 0.05). Multivariate logistic regression showed that left ventricular ejection fraction, National Institute of Health Stroke Scale scores, and Oxfordshire Community Stroke Project classification were independent predictors of 3-month disability (P < 0.05). (2) The National Institute of Health Stroke Scale scores and Oxfordshire Community Stroke Project classification at admission were included in model 1, which added the left ventricular ejection fraction as model 2, and all univariate significant difference variables were included in model 3. Receiver operating characteristic analysis showed the area under the curve values of 0.769, 0.806, and 0.824 for the models used to predict the 3-month disability rate. (3) The optimal cutoff for left ventricular ejection fraction from the receiver operating characteristic curve was 60.25%, classifying patients into low left ventricular ejection fraction (≤ 60.25%) and high left ventricular ejection fraction (> 60.25%) groups. The 3-month disability rate was higher in the low left ventricular ejection fraction group than in the high left ventricular ejection fraction group (44% vs. 26%, P=0.002). These findings highlight that reduced left ventricular ejection fraction plays an important role in the assessment of functional disability 3 months after acute ischemic stroke. Left ventricular ejection fraction can be incorporated into routine prognostic assessments when clinically evaluating the prognosis of ischemic stroke.

Key words: acute ischemic stroke, transthoracic echocardiography, three-dimensional speckle tracking echocardiography, prognosis, disability, left ventricular ejection fraction, modified Rankin Scale, receiver operating characteristic curve, engineered tissue construction

CLC Number: