Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 7986-7990.doi: 10.3969/j.issn.2095-4344.2012.43.002

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Compound bone morphogenetic protein-alpha-cyanoacrylate biological glue repairs mandibular defects in rats

Wang Xin1, 2, Xie Fu-qiang 2, Zhang Yun1, 2, Sun Jian2   

  1. 1School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China
    2Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
  • Received:2012-01-14 Revised:2012-03-12 Online:2012-10-21 Published:2012-10-21
  • Contact: Xie Fu-qiang, Professor, Chief physician, Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China xiefq@lzu.edu.cn
  • About author:Wang Xin, Studying for master’s degree, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China; Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China wang_x10@ lzu.edu.cn

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Abstract:

BACKGROUND: Bone morphogenetic protein 2 is the strongest in the family of bone morphogenetic proteins which can induce osteogenesis separately.
OBJECTIVE: To evaluate the effectiveness and feasibility of implantation of the compound bone morphogenetic protein- cyanoacrylate biological glue in the reconstruction of rat mandibular defects.
METHODS: Totally 54 male Wistar rats were divided into three groups randomly and equally: The experimental group, the control group (the chitosan group) and the blank group. Mandibular defects of rats were repairing by implanting the compound bone morphogenetic protein-α-cyanoacrylate biological glue in the experimental group. While mandibular defects of the chitosan group were repaired only with chitosan. The blank group received no implantation.
RESULTS AND CONCLUSION:①X-ray examination: At weeks 3, 6, 9 postoperation, the area of residual mandibular defects in the experimental group was smaller than that of the other two groups. There was a statistically significant difference between the experimental and the other two groups (P < 0.05). ②Histopathology observation: The new bone mass in the experimental group was superior to those in the other two groups. It is demonstrated bone morphogenetic protein α-cyanoacrylate biological glue can be used to restoration of rat mandibular bone defects and significantly promote the mandibular repair.

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