Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 7981-7985.doi: 10.3969/j.issn.2095-4344.2012.43.001

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Promotive effect of injectable thermo-sensitive icariin chitosan hydrogel on radial fracture healing in rabbits

Wang De-yin, Rui Gang, Li Pian, Feng Zu-de, Feng Jin-yi   

  1. Department of Emergency, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
  • Received:2012-01-03 Revised:2012-02-29 Online:2012-10-21 Published:2012-10-21
  • Contact: Rui Gang, Chief physician, Master’s supervisor, Department of Emergency, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China reigang@ yahoo.com.cn
  • About author:Wang De-yin★, Master, Associate chief physician, Department of Emergency, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China

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Abstract:

BACKGROUND: Epimedium has in vitro promotive effects on osteoblast osteogenesis, differentiation and maturation. Besides, it can stimulate bone formation.
OBJECTIVE: To observe the repair effect of injectable thermo-sensitive icariin chitosan hydrogel on radial fracture healing in rabbits.
METHODS: The left and right radius was cut off from 36 rabbits under anesthesia and randomly divided into experimental group, control group and blank group. The rabbits in the former two groups were injected with injectable thermo-sensitive icariin chitosan hydrogel and chitosan hydrogel around the fracture ends, respectively. The rabbits in the blank group had no treatment.
RESULTS AND CONCLUSION: Fractures in each group were cured at week 6 after surgery. X-ray films showed that average gray value per unit area and osteoblast count of the experimental group were significantly higher than those of the control and blank groups (P < 05). Moreover, the osteoblast proliferation was active in the experimental group. These results suggest that injectable thermo-sensitive icariin chitosan hydrogel can improve osteoblast activity and promote the fracture healing.

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